1 / 22

GALECTIN -3

MEDIC. GALECTIN -3. MAI QUANG VINH LONG, MD. CASE. A 53 y.o . man presents with increased shortness of breath on exertion for 2 months.

schifferm
Télécharger la présentation

GALECTIN -3

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. MEDIC GALECTIN -3 MAI QUANG VINH LONG, MD

  2. CASE • A 53 y.o. man presents with increased shortness of breath on exertion for 2 months. • Known for heart failure 2 months ago, sometimes had angina. Smoked 10 cigarettes a day for 20 years. No history of myocardial infarction.No family history of CAD. • P/E: Pulse 72bpm, BP 105/60mmHg, systolic apical murmur 3/6 , lung auscultation is normal , unremarkable abdominal exam and no peripheral oedema

  3. Treatment • Spironolactone 50mg • Losartan 50mg • Bisoprolol 5mg • Acenocoumarol 4mg • Atorvastatin 20mg

  4. AFTER 2 MONTHS AFTER 3 MONTHS

  5. GALECTIN-3Biomarker of myocardial fibrosis

  6. GALECTIN-3 • Galectin-3 is a protein- secreted by activated macrophages- that modulates several physiological and pathological processes at contribute to HF, including fibrosis, or stiffening, in the heart muscle, which impairs the heart’s ability to pump. • Galectin-3 is recommended for additive risk stratification in patients hospitalized with acute decompensated HF as well as in ambulatory patients with chronic stable HF • Persistently elevated galectin-3 predicts new-onset HF 

  7. Biomarkers Indications for Use In Heart Failure Other biomarkers of injury or fibrosis include soluble ST2 receptor, galectin-3. 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure

  8. Khuyến cáo của Hội tim mạch quốc gia Việt Nam về chẩn đoán và điều trị suy tim: Cập nhật 2018

  9. Khuyến cáo của Hội tim mạch quốc gia Việt Nam về chẩn đoán và điều trị suy tim: Cập nhật 2018

  10. CARDIAC FIBROSIS MANAGEMENT • Galectin-3 Inhibitors • Angiotensin receptor blockers (ARBs) :candesartan and losartan • ACE inhibitors : lisinopril • Aldosterone antagonists: Spironolactone and eplerenone

  11. KEY POINTS • Galectin-3 is a mediator of cardiac fibrogenesis, which leads to development and worsening of heart failure • Knowing the level of galectin-3, can assist in optimization of patient management and selection of the appropriate treatment options. • Cardiac fibrosis management: ACE, ARB, Aldosterone antagonists

  12. REFERENCES • 1. Sharma uC, Pokharel s, van Brakel TJ, van BerloJH,Cleutjens JP, schroen B, et al. galectin-3 marks activated macrophages in failure-prone hypertrophied hearts andcontributes to cardiac dysfunction. Circulation. 2004;110:3121–8.2. Van kimmenade RR, JanuzziJlJr, ellinor PT, sharmauC,Bakker JA, low Af, et al. utility of amino-terminal probrainnatriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol.2006;48:1217–24.3. lokdJA, van dermeer P, Bruggink-André de la Porte PW,lipsic e, van Wijngaarden J, HillegeJl, et al. Prognostic value of galectin-3, a novel marker of firosis, in patients with chronic heart failure: data from the deAl-Hf study. Clin Res Cardiol. 2010;99:323–8.4. Milting H, ellinghaus P, seewald m, Cakar H, BohmsB,kassner A, et al. Plasma biomarkers of myocardial firosis and remodeling in terminal heart failure patients supported by mechanical circulatory support devices. J Heart lung Transplant. 2008;27:589–96.5. Lin yH, linly, Wu yW, Chienkl, lee Cm, Hsu RB, et al. The relationship between serum galectin-3 and serum markers of cardiac extracellular matrix turnover in heartfailure patients. ClinChimActa. 2009;409:96–9..6.PhạmNguyễnVinh.Khuyến cáo của Hội tim mạch quốc gia Việt Nam về chẩn đoán và điều trị suy tim: Cập nhật 2018

More Related