Sequences comparison. 1 Issues Similarity gives a measure of how similar the sequences are. Alignment is a way to make clear the correspondence between similar characters or sub-strings from the sequences.
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By ostinmannualBioinformatics and BLAST. Overview. Recap of last time Similarity discussion Algorithms: Needleman-Wunsch Smith-Waterman BLAST Implementation issues and current research. Recap from Last Time. Genome consists of entire DNA sequence of a species DNA is the blueprint
By MercySequence analysis of nucleic acids and proteins: part 1. Similarity search Lecture by Terry Speed. Based on Chapter 3 of Post-genome Bioinformatics by Minoru Kanehisa, Oxford University Press, 2000.
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By romanSequence Alignments Some key terms and concepts : Indel (insertion and deletion) Pairwise sequence alignment ( eg . Blast) versus multiple sequence alignment ( eg . Clustal ) Scoring models and matrices (applies to both amino-acid and nucleotide sequences)
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