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Supplemental Figure:2

B. Fold Change. Fold Change. CREBH-N. CHOP. ATF4. sXBP1. ATF6 ? -N. Fold Change. Fold Change. ? - tubulin. ? - tubulin. ? - tubulin. Supplemental Figure:2. ? - tubulin. ? - tubulin. A. *. *. *. -. -. -. +. +. +. -. -. +. +. Empty vector. Empty vector. +. -. D. -.

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Supplemental Figure:3

ATF6 ? -N. ? - tubulin. hATF6 ? -Luc. D. Supplemental Figure:3. Fold change. -. C. ERR ?. +. +. +. -. -. PGC1 ?. **. A. B. **. **. Human 2077 ggg aggtca agc 2066. Ad-GFP. **. Relative ATF6 ? mRNA level. Human 1612 gat aggtca caa 1601. Ad- shUS. Ad-GFP. Ad- shERR ?.

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Supplemental Figure:2

Supplemental Figure:3