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Analysis of Gene Expression Changes in Response to ER Stress Markers and Transcription Factors

This study investigates the fold changes in expressions of various markers (CREBH, sXBP1, ATF4, and ATF6α) involved in the endoplasmic reticulum (ER) stress response. Using luciferase reporter assays (5XATF6αRE and G6Pase-Luc), the interactions and regulatory effects of these key transcription factors were analyzed. The results indicate significant variances in expression levels, highlighting the involvement of pathways coordinated by CREBH, sXBP1, and ATF4 in cellular stress management. Supplemental figures include data on α-tubulin levels as a reference.

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Analysis of Gene Expression Changes in Response to ER Stress Markers and Transcription Factors

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  1. B Fold Change Fold Change CREBH-N CHOP ATF4 sXBP1 ATF6α-N Fold Change Fold Change α-tubulin α-tubulin α-tubulin Supplemental Figure:2 α-tubulin α-tubulin A * * * - - - + + + - - + + Empty vector Empty vector + - D - CHOP ** C 5XATF6αRE (UPRE)-Luc * - - - - - CREBH sXBP1 ATF6α 5XATF6αRE (UPRE)-Luc CHOP ATF4 G6Pase-Luc GRP78-Luc CRP-Luc Fold Change - Empty vector + + - ATF6α E ATF4 C/EBP Empty vector - + + - sXBP1 * Empty vector - + - CREBH +

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