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Unit 8: Physiology

Unit 8: Physiology. Immune System Part 1: Infectious Disease. Chapter 40-1 & 2. Infectious Disease. Disrupts normal body function (homeostasis) Caused by a pathogen. Pathogen : anything that invades your body & causes a disease Ex: bacteria, protozoan, fungi, viruses, parasites, worms

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I. ?? T Cells II. Invariant TCR T Cells

I. ?? T Cells II. Invariant TCR T Cells. ?? T Cells in Autoimmune and Infectious Disease. ?? T cells can account for 30% of the T cell infiltrate in MS lesions (Wucherpfennig, K. W., et. al. PNAS 89:4588).

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A daptive I mmune S ystem

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Aims

Aims. Describe the innate immune system. Compare and contrast the innate immune system with the adaptive immune system. Readings: Abbas & Lichtman, Chapters 1 & 2. Innate Immune System. Physical barriers to infection Epithelial barrier (skin) Mucus, saliva, tears Phagocytic cells

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Immunology

Immunology. Chapter 1 Dr. Capers IRSC. History. Discipline of immunology grew out of observation that individuals who recovered from infectious diseases were protected from disease 15 th Century Chinese and Turks tried to prevent smallpox

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Exam Format

Exam Format. 100 points - 60 pts mandatory; 40 points where 4, 10 point questions will be chosen Some open-ended questions, some short answer. Kuby question. Cytokines. Terminology How do cytokines achieve their effect? Radius of action Specific cytokines - also Th1 vs Th2 cytokines

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Exam Format

Exam Format. 100 points - 60 pts mandatory; 40 points where 4, 10 point questions will be chosen Some open-ended questions, some short answer. Kuby question. Cytokines. Terminology How do cytokines achieve their effect? Radius of action Specific cytokines - also Th1 vs Th2 cytokines

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Immunology

Immunology. Adaptive immunity. T cells and B cells recognize antigen differently. B cells (antibody cells) recognize antigen alone B cells recognize intact antigen T cells recognize antigen + MHC T cells recognized processes antigen. T lymphocytes. Mature in the thymus

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Immune system

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