Supplementary Table S1. Respiration rates of the mitochondria isolated from the florets of thermogenic male part of the spadices of D. vulgaris . O 2 uptake (nmol O 2 /min/mg protein). Respiration. 20 o C. 35 o C.
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Cytochrome P450. F.G. Guengerich S.D. Black T. Wolff, G. Strobl and H. Greim Sean Ekins F.J. Gonzalez. Lecture. Introduction to Cytochrome P450. Cytochrome P450 reactions Cytochrome P450 Structure P450 Substrates and Inhibitors prediction and design. Introduction.
Cytochrome P450. Heme protein Terminal oxidase of the mixed-function oxidase (MFO) electron-transfer system Located in the smooth endoplasmic reticulum of all major organs and tissues Uses NADPH as a source of reducing equivalents Inducible. Overall reaction. R-H + O 2 + NADPH + H +
Cytochrome P450. Lecture 8 Modified from textbooks, journals and internet sources. Introduction. Cytochrome P450 (P450) very large and diverse superfamily of hemoproteins range of proteins found in all domains of life
CYTOCHROME SYSTEM. &. DRUG METABOLISM. CYTOCHROME SYSTEM. &. DRUG METABOLISM. ILOs. Revise the intent of drug metabolism and its different phases Define the role of cytochrome system in relation to drug metabolism
Cytochrome P450 Monooxygenases. William Green Leland Taylor 3/29/11. Background. P450s are a group of heme-containing enzymes that utilize NADPH and/or NADH to produce functionalized organic substrates
Cytochrome P450 Monooxygenases. William Green Leland Taylor 4/12/11. Background. P450s are enzymes that produce functionalized organic substrates Two main pathways of P450 monooxygenasese : Biosynthetic Pathway:
Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition. Carol A. Kemp, Jack U. Flanagan, Annamaria J. van Eldik, Jean-Didier Mare´chal, C. Roland Wolf, Gordon C. K. Roberts,§ Mark J. I. Paine & Michael J. Sutcliffe J. Med. Chem. 2004.
Cytochrome P450 Monooxygenases. William Green Leland Taylor 4/12/11. Background. P450s are heme -containing enzymes that produce functionalized organic substrates Two main pathways of P450 monooxygenasese : Biosynthetic Pathway: