'Fgfr3' diaporamas de présentation

4 receptors: FGFR1-4 22 ligands: FGF1-23

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Molecular roots of FGFR3-related skeletal dysplasia

Molecular roots of FGFR3-related skeletal dysplasia. Pavel Krejci , PhD Institute of Experimental Biology, Masaryk University, Brno Department of Cytokinetics, Institute of Biophysics AVCR, Brno Cedars-Sinai Medical Center, Los Angeles, USA.

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Molecular roots of FGFR3-related skeletal dysplasia

Molecular roots of FGFR3-related skeletal dysplasia. Pavel Krejci , PhD Institute of Experimental Biology, Masaryk University, Brno Department of Cytokinetics, Institute of Biophysics AVCR, Brno Cedars-Sinai Medical Center, Los Angeles, USA.

364 views • 36 slides

4 receptors: FGFR1-4 22 ligands: FGF1-23

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Regulation of cell function by FGFR3 receptor tyrosine kinase

Regulation of cell function by FGFR3 receptor tyrosine kinase. Pavel Krej ci Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA Institute of Experimental Biology, Masaryk University, Brno, Czech Republic. Fgfr3 +/-. Fgfr3 -/-. Fgfr3 +/-. Fgfr3 -/-. Tail.

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Regulation of cell function by FGFR3 receptor tyrosine kinase

Regulation of cell function by FGFR3 receptor tyrosine kinase. Pavel Krej ci, PhD Institute of Experimental Biology, Masaryk University, Brno, Czech Republic. Fgfr3 +/-. Fgfr3 -/-. Fgfr3 +/-. Fgfr3 -/-. Tail. Cell 1996, 84(6):911-21. FGFR3-related skeletal dysplasias.

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INTRODUCTION

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FGFR3

FGFR3. P-ERK. ACTIN. FGFR3. 1. 2. 3. 4. 5. 6. 7. Supplemental Figure 5.

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Differential signaling via Fgfr gradients (e.g. Fgfr3)

A B. M1. M1. S1. S1. A1. A1. V1. V1. ?. ?. Wt/cont +Fgf8 +sFgfr3 Fgfr3 * Fgfr3 ko. Differential signaling via multiple Fgf ligands. Fgf8/15/17 Fgf2.. and other Fgfs. Differential signaling

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BxPC-3

FGFR3. DAPI. MERGE. BxPC-3. Capan-2. PANC-1. MiaPaCa-2. NHEK. Supplemental Figure 4.

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