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Differential Signaling and Proliferative Properties of Fgf Ligands in Progenitor Patterns

This study investigates the differential signaling of multiple Fgf ligands, including Fgf8, Fgf15, and Fgf17, through their receptor, Fgfr3, in relation to cell proliferation and progenitor population characteristics. Key genes like Pax6, Emx2, Coup-Tf1, and Sp8 are examined for their roles in determining correct area location and size in developmental contexts. The research highlights the importance of Fgfr gradients in guiding cellular behavior and patterning during development.

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Differential Signaling and Proliferative Properties of Fgf Ligands in Progenitor Patterns

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  1. A B M1 M1 S1 S1 A1 A1 V1 V1 ? ? Wt/cont +Fgf8 +sFgfr3 Fgfr3* Fgfr3 ko Differential signaling via multiple Fgf ligands Fgf8/15/17 Fgf2.. and other Fgfs Differential signaling via Fgfr gradients (e.g. Fgfr3) Patterning Cell proliferative properties Tc / TG1 Proliferative capacity / phase Progenitor subpopulation Pax6 Emx2 Coup-Tf1 Sp8 Correct area location and size

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