'Gene order' diaporamas de présentation

6.096 Lecture 10

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Orthology predictions for whole mammalian genomes

Orthology predictions for whole mammalian genomes. Leo Goodstadt MRC Functional Genomics Unit Oxford University. Bioinformatic and Comparative Genome Analysis Course HKU-Pasteur Research Centre - Hong Kong, China August 17 - August 29, 2009. Finishing.

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Gene Prediction: Computational Challenge

Gene Prediction: Computational Challenge. Gene : A sequence of nucleotides coding for protein Gene Prediction Problem : Determine the beginning and end positions of genes in a genome. Central Dogma and Splicing. intron1. intron2. exon2. exon3. exon1. transcription. splicing. translation.

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The Life Cycle

The Life Cycle. P. Neuroptera Coleoptera Hymenoptera Lepidoptera Mecoptera Siphonoptera Strepsiptera Diptera. ~250 Mya. Nematocera Brachycera Muscomorpha Cyclorrhapha Schizophora Calyptrata Acalyptrata. Camillidae Steganinae Cladocheata etc Zaprionus etc

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Comparative Genomics Sridhar Hannenhalli sridhar@umiacs.umd

Comparative Genomics Sridhar Hannenhalli sridhar@umiacs.umd.edu. " Nothing in biology makes sense except in the light of evolution ." Theodosius Dobzhansky, 1932. What is comparative genomics.

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Outline

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Research on Mitochondrial Genomes Lectures for 4Y03

Research on Mitochondrial Genomes Lectures for 4Y03. Paul Higgs Dept. of Physics, McMaster University, Hamilton, Ontario. Supported by Canada Research Chairs and BBSRC. Building a database for mitochondrial genomes. Large scale - gene order evolution.

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Genome Trees and the Nature of Genome Evolution

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Gene Geography

3c. Gene Geography. Dan Graur Department of Biology and Biochemistry. Gene density (genes/Kb) Mycoplasma genitalium 0.8 Escherichia coli 0.6 Saccharomyces cerevisiae 0.5 Caenorhabditis elegans 0.2 Arabidopsis thaliana 0.2 Homo sapiens 0.03

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"Quadratic time algorithms for finding common intervals in two and more sequences"

"Quadratic time algorithms for finding common intervals in two and more sequences". by T. Schmidt and J. Stoye, Proc. 15th Annual Symposium on Combinatorial Pattern Matching , Lecture Notes in Computer Science 3109, pp. 347-358 (2004). Presented by Gangman Yi. Overview. Introduction

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Eukaryotic Chromosome Mapping

Eukaryotic Chromosome Mapping. Using Genetic Recombination to Estimate Distances Between Genes. Linked Genes. F1: Red eyes, Beige body RrBb. Independent Assortment vs. Gene Linkage. Example from Drosophila Red eyes, x Pink eyes Beige body Ebony body

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Yeast genome sequencing: the power of comparative genomics

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Plant genomes: phenotypes evolving by new rules

Plant genomes: phenotypes evolving by new rules. Todd J. Vision Department of Biology University of North Carolina at Chapel Hill. Functional conservation of genes across distantly related plants. GA1 (a dwarf gibberellin insensitive mutant from Arabidopsis )

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Lecture 6

Lecture 6. Linkage. A geneticist isolates two mutations: ? A = tall ? a = short ? H = hairy ? h = no hair and constructs the following pure-breeding stocks: AAhh and aaHH Tall short No hair hairy

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Theoretical methods for predicting gene function I. Overview

Theoretical methods for predicting gene function I. Overview Inspired by : P. Bork et al. J. Mol. Biol. (1998),283,707-725 Predicting Function: From Genes to Genomes & Back. S. Wodak, ULB Inter-university DEA/DES in Bioinformatics. BIOLOGICAL FUNCTION. What is biological function?.

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Igor Sharakhov

Igor Sharakhov. High Rates of Genome Rearrangements in Malaria Mosquitoes, Anopheles gambiae and A. funestus. University of Notre Dame, USA. Genus Anopheles Subgenus Cellia. Series Pyretophorus gambiae species complex. Myzomyia funestus group. A. gambiae. A. funestus.

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Does gene order matter?

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Molecular Evolution

Molecular Evolution . The fact that all species utilize the same genetic code to synthesize proteins argues for a common ancestry to all life on earth. Comparing Chromosome banding patterns, DNA sequences, or proteins.

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Longer regions have more crossovers and thus higher recombinant frequencies.

Longer regions have more crossovers and thus higher recombinant frequencies. Three Point Mapping: Forward Analysis. Single Crossovers Region I (SCO I) jv se + h + jv + se h. 6.8 m.u. 0.5 m.u. jv. se. h. jv +. se +. h +. Single Crossovers Region II (SCO II) jv se h +

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LEQ: What can go wrong in this process

LEQ: What can go wrong in this process. 10.16. Mutations. A change in the nucleotide sequence of DNA Ultimate source of genetic diversity Gene vs. Chromosome. Gene Mutations.

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