'Hydrophobic pocket' diaporamas de présentation

Enzyme Mechanisms and Regulation

Enzyme Mechanisms and Regulation. Andy Howard Introductory Biochemistry, Fall 2008 Tuesday 28 October 2008. How do enzymes reduce activation energies?. We can illustrate mechanistic principles by looking at specific examples; we can also recognize enyzme regulation when we see it. Regulation

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What does the transition state of this reaction look like?

What does the transition state of this reaction look like?. Note that a key step in the previous mechanism is the loss of an alkoxy (sugar) moiety from the position (C2) next to the carboxylate group. This creates a carbocation (Sn1 process), which is sp2 hybridized.

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3-D Structure / Function

3-D Structure / Function. Myoglobin/ Hemoglobin. First protein structures determined Oxygen carriers Hemoglobin transport O 2 from lungs to tissues Myoglobin O 2 storage protein. Mb and Hb subunits structurally similar. 8 alpha-helices Contain heme group Mb monomeric protein

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(ii)

(i) symmetric contacts (NOE) with Me-18,19. Chiral Solvation of BNDHP by Cholate Micelles. (i) A hydrophobic pocket is formed by facial methyl groups of an antiparallel dimeric unit of cholate, and Me-21 lies in the hydrophobic plane. Me 19. Me 18. Me 21. H5. H6. H4. H7. H3.

191 views • 1 slides