'Mismatch repair' diaporamas de présentation

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DNA Damage and Repair

DNA Damage and Repair. Why do we care? Genetic diseases Cancer. Cellular Responses to DNA Damage. Reversal of DNA Damage Enzymatic photoreactivation Ligation of DNA strands Repair of photoproduct Tolerance of DNA Damage

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Tetrad analysis

Tetrad analysis. ?????. ?????/???/???? ?????. ?????. Replica plating. Replica plating. -URA. -TRP. -ADE. -LYS. YePD. URA3 TRP1 ade2 lys2. URA3 trp1 ade2 lys2. ab X a + b +. A. B. a. b. A. B. A. b. A. B. A. b. a. b. a. B. a. b. a. B. PD. =. NPD. A. B. A. B.

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DNA repair

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Leicester Warwick Medical School

Leicester Warwick Medical School. Neoplasia III Why and How do Tumours Occur? Professor Rosemary A Walker raw14@le.ac.uk Department of Pathology. WHY DO TUMOURS DEVELOP?. Intrinsic factors Extrinsic factors. INTRINSIC FACTORS. Inherited susceptibility Host factors age Immune status

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DNA Damage, Mutations, and Repair

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Welcome! The Topic For Today Is CREOG ONC REVIEW Hosted by Emily Ko, MD

Welcome! The Topic For Today Is CREOG ONC REVIEW Hosted by Emily Ko, MD. CREOG ONC REVIEW. Topic 1: 200. Question: Name 2 tumor suppressor genes Answer P53, Rb, WT1, BRCA1, BRCA2 Usually autosomal recessive. Back. Topic 1: 400. Question: Name the 5 stages of the cell cycle Answer

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Figure 30-28 The replication of E. coli DNA.

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Figure 30-28 The replication of E. coli DNA.

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Bacterial Genetics

Bacterial Genetics. Chapter 8. The Problem of Antibiotic Resistance. Staphylococcus aureus Common Gram + bacterium Multi-drug resistant strains are prevalent in hospitals These are described as methicillin-resistant Staphylococcus aureus (MRSA) Antibiotic resistance is a genetic event.

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DNA metabolism DNA replication DNA repair DNA recombination

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Announcements

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Mutation

Mutation. ??????? ???? ????? ?????? ??????? ?????? ?????. Dr. Parvin Pasalar Tehran University of Medical Sciences. Mutation. Definition: An un- repaired damages to DNA Causes: It may be spontaneous or induced because of different agents Classifications:

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MSH2 (MutS homolog, hereditary non-polyposis colon cancer)

MSH2 (MutS homolog, hereditary non-polyposis colon cancer). By Katie Butler. To determine function of MSH2 we study MutS in E. Coli. Why? Pathway better understood Pathway highly conserved in humans. Role of MutS. Mismatch Repair Machinery. DNA Damage.

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The Damage and Repair of DNA

The Damage and Repair of DNA. Two main types of DNA damage: *point mutations *structural changes. The molecular basis of point mutations. 1. Base substitution (mismatches) transition transversion. 2. Tautomeric shift. Gene Mutation. The molecular basis of point mutations.

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Lecture 24: Mutation and DNA repair

Lecture 24: Mutation and DNA repair. Announcements. Deamination of cytosine and adenine. Base analogs. Alkylating agents. Intercalating agents. UV-induced pyrimid ine dimers. High energy particles can damage DNA. Direct photoreactivation. Base excision repair.

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DNA Repair Supplement

DNA Repair Supplement. Read and digest please. Things that Damage DNA. Radiation - Cosmic Chemicals - in the environment DNA Replication Accidents Heat (spontaneous chemical alterations). Types of DNA Damage.

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E.coli systems and recombination: Determinants of diversity: Overall aims ML

E.coli systems and recombination: Determinants of diversity: Overall aims ML. Nine/ten lectures with Key topics. Homologous recombination and DNA repair Role of methylation and repair. Role of Plasmids; control of replication, transfer and stability.

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Announcements

Announcements. Exam 3 is next Wednesday, 3/28 Material for Exam 3: Lectures 19-25 Topics: DNA replication, transcription, RNA processing, translation, cancer, DNA damage and DNA repair (assigned reading from Chaps. 11, 14, 15, 16) Key terms #7-8 Homeworks 5-7

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