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The Damage and Repair of DNA

The Damage and Repair of DNA. Two main types of DNA damage: *point mutations *structural changes. The molecular basis of point mutations. 1. Base substitution (mismatches) transition transversion. 2. Tautomeric shift. Gene Mutation. The molecular basis of point mutations.

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The Damage and Repair of DNA

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  1. The Damage and Repair of DNA Two main types of DNA damage: *point mutations *structural changes The molecular basis of point mutations 1. Base substitution (mismatches) transition transversion 2. Tautomeric shift

  2. Gene Mutation The molecular basis of point mutations 3. Base analogs and chemical mutagens

  3. DNA Damage The molecular basis of structural damage 1. Hydrolytic damage Deamination N-glycosidic bond – very weak and easily broken Depurination Deamination

  4. DNA Damage The molecular basis of structural damage 2. Alkylation

  5. DNA Damage The molecular basis of structural damage 3. Oxidation and Radiation

  6. Repairing Damages Bases 1. Mismatch repair (MMR) Dam methylase: MutS:

  7. Repairing Damages Bases 1. Mismatch repair (MMR)

  8. Repairing Damages Bases 2. Photoreactivation

  9. Repairing Damages Bases 3. Repair of alkylation

  10. (BER) Repairing Damages Bases 4. Base excision repair (BER)

  11. Repairing Damages Bases 4. Base excision repair (BER)

  12. Repairing Damages Bases 5. Nucleotide excision repair (NER)

  13. DNA Repair 7. Double Strand Break Repair (DSB) Nonhomologous End-Joining (NHEJ) Ku XRCC4 DNA-PKcs Artemis Ligase

  14. DNA Repair 8. Double Strand Break (DSB) repair (Homologous Recombination)

  15. DNA Repair 8. Double Strand Break (DSB) repair (Homologous Recombination)

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