'Negative selection' diaporamas de présentation

Origin of diversity Bibliography

Origin of diversity Bibliography. Antibody diversity: one enzyme to rule them all Michel C Nussenzweig & Frederick W Alt Nature Medicine 10;1304-5;2004 Immunobiology Janeway et al 6 th ed 2005 (or 7 th ed. 2008). Clonal selection theory. ????? ???? ?? ?????????? ?????. ?? ?? ???? ??????

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Natural Selection

Natural Selection. Natural Selection. An Adaptive Mechanism. Evolutionary Mechanisms. Genetic Drift Migration Mutations Natural Selection. Non-adaptive. Adaptive. Darwin. Evolution acts through changes in allele frequency at each generation According to Darwin, this happens via

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Transgenic animals : Stable integration of exogenous DNA in the genome

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Gene targeting

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Introduction to

Introduction to. Bioinformatics. Introduction to Bioinformatics. LECTURE 6: Natural selection at the molecular basis * Chapter 6: Fighting HIV. Introduction to Bioinformatics LECTURE 6: NATURAL SELECTION AT THE MOLECULAR BASIS. 6.1 Acquired Immune Deficiency Syndrome (AIDS)

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Immune System How we stay alive though vastly outnumbered

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Chapter 10 T-Cell Maturation, Activation, and Differentiation

Chapter 10 T-Cell Maturation, Activation, and Differentiation. MHC. CD4/CD8. TCR. zz. gde. Dec 7 & 12, 2006. ????????? 1. ???? positive selection ? negative selection ? ????????? 2. T ???? costimulatory signals ??????? 3. ???? clonal anergy ?

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Non-stationary population genetic models with selection: Theory and Inference

Non-stationary population genetic models with selection: Theory and Inference. Scott Williamson and Carlos Bustamante. Cornell University. Inferring natural selection from samples. Statistical tests of the neutral theory (lots) Methods for detecting selective sweeps (lots)

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Molecular Evolution with an emphasis on substitution rates

Molecular Evolution with an emphasis on substitution rates. Gavin JD Smith State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology The University of Hong Kong

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Development of Thymus

Development of Thymus. Bone marrow cells colonize thymic anlage in fetus. Fully Developed Thymus. Occurs at birth in humans. Waves then Steady state. Involutes after puberty. preTCR. Precursor chooses. CD3. Maturation of ???? T Cells. Specific Distribution of Cells.

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Reminders

Reminders. Midterm test on Tuesday Review session Saturday 4-6 PM, here. Reading: Chapters 3, 5, 6, 8.13-8.15. Natural killer (NK) Cells a link between innate and adaptive immunity.

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Christina Ziegler Feb 15 th 2010

Christina Ziegler Feb 15 th 2010. Mechanisms of tolerance induction. Clonal deletion negative selection of thymocytes with high affinity TCR for MHC:self -antigen (central tolerance) (2) Clonal anergy

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APECED

APECED. autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. development of thymocytes in the thymus gland stochastic process -T-cell antigen receptors that can bind to self antigens negative selection bone marrow derived dendritic cells and macrophages; thymic epithelial cell

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Chapter 16- Tolerance and autoimmunity

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Evolution of individual genes in humans

Evolution of individual genes in humans. Are there any examples of genes that are actively evolving in humans (but which are static in other primates)? If so, how do we distinguish genes that are under POSITIVE SELECTION from those that are under PURIFYING SELECTION?. Four papers to read:.

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V-Detector: A Negative Selection Algorithm

Computer Science Research Day The University of Memphis March 25, 2005. V-Detector: A Negative Selection Algorithm. Zhou Ji, advised by Prof. Dasgupta. Background. Immune system is a group of cells and organs that work together to fight infections in our bodies. Background.

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Bone Marrow Transplantation

Bone Marrow Transplantation. Unlike solid organ transplant, in bone marrow transplantation (BMT) the immunology goes two ways. There is host vs. ?graft disease, but also graft vs. host disease (GVHD) because the marrow graft ?contains functional immune cells.

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