Nod mice - PowerPoint PPT Presentation

Chapter 3

Chapter 3. Animal Models Type 1 Diabetes. Diabetes 2012. Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope Carolin Daniel... Harald von Boehmer1,2JEM 2011. 3-4 wk vaccination. Register 3 mimotope. 12-14 wk vaccination.

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Figure Added in “Proof”: 44 week native insulin gene knockout with mutated B16:alanine insulin Transgene: No Insulitis

Figure Added in “Proof”: 44 week native insulin gene knockout with mutated B16:alanine insulin Transgene: No Insulitis. See Nakayama et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435:220, 2005.

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