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Role of Insulin Epitope in Type 1 Diabetes Development in NOD Mice

This study examines the impact of a mutated B16:alanine insulin transgene on NOD mice, showing that a knockout of the native insulin gene has significant effects on insulitis development. The findings, presented in Nakayama et al. (2005), highlight the critical role a specific insulin epitope plays in the pathogenesis of type 1 diabetes, suggesting potential pathways for genetic and therapeutic interventions in autoimmune diabetes.

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Role of Insulin Epitope in Type 1 Diabetes Development in NOD Mice

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  1. Figure Added in “Proof”: 44 week native insulin gene knockout with mutated B16:alanine insulin Transgene: No Insulitis See Nakayama et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435:220, 2005

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