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Pattern of p63 mutations and their phenotypes—update

Pattern of p63 mutations and their phenotypes—update. American Journal of Medical Genetics Part A Volume 140A, Issue 13, pages 1396-1406, 11 MAY 2006 DOI: 10.1002/ajmg.a.31271 http://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.31271/full#fig1. Tutti gli epiteli stratificati

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Cleaved Casp8

p63 overexpression in NHEK. Ctl. Δ Np63 α. RT-PCR. Δ Np63 α. GAPDH. W.B. V inc. D N p63 a. Cleaved Casp8. p63. DAPI. Ctl. Δ Np63 α. RT-PCR, Western Blot and immunofluorescence analysis of NHEK transfected with 2 u g of a control plasmid (Ctl) and ΔNp63α expression construct.

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Overexpr.

Overexpr. RNAi. Effect of p63 siRNA (19). Major role. C. 24h. 48h. siRNA. C. CK1. Both. CK14. p63 (Refs 24, 25). CK18. ?. DSC1. TAp63 ( Ref. 24 ). DSC3. Both (Ref. 24). PCNA. p63 (Ref. 17). EGF-R. TAp63 (Ref. 61). E-cad. p63. ESR. ?. c-Jun. Both. JunB. Both. T-cad.

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