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2.12k views • 91 slides
Development and Longevity

Development and Longevity

Development and Longevity. Weiqing Li. Department of Biological Structure. University of Washington, Seattle. Conj 542, 1/24/12. Developmental Biology. Mechanisms of Aging. Stem Cell Research. Development. Adulthood. ?. 1. Antagonistic pleiotropy? 2. Shared signaling cascades?

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696 views • 56 slides
p110

p110

EGFR-PI3K-mTOR signaling in glioma. EGFR. p. p. PIP 3. PIP 2. p. p. p. p85. p110. PDK 1. PI3K. PLC ?. PTEN. PKC. Ser473. Thr308. MAPK. p. p. Akt. p. TSC1/TSC2. mTOR. Raptor. Rictor. mTOR. mTORC1. mTORC2. mTOR. p. p. 4E-BP. S6K. Autophagy. Cell growth, Cell death.

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348 views • 1 slides
PDK-1 Signaling Pathway

PDK-1 Signaling Pathway

As a member of AGC kinases family, PDK-1, a protein of 556 amino acids, is composed of serine and threonine kinases. The catalytic domain of these serine and threonine kinases show a sequential similarity with cAMP-dependent protein kinase 1 (PKA), cGMP-dependent protein kinase (PKG) and protein kinase C (PKC). There are two phosphorylation sites that many AGC kinases and they are to regulate the activity of AGC kinases.

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33 views • 1 slides

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