Introduction. Clare Kahn, Ph.D. Vice President, US Regulatory Affairs Cardiovascular, Urogenital & Metabolic Products, GlaxoSmithKline. Carvedilol. Pharmacological Properties Nonselective b -adrenergic receptor antagonist ? 1 -adrenergic receptor antagonist. Mild. Moderate. Severe.
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Vaccines and Related Biological Products Advisory Committee Meeting Prevnar 13: Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM 197 Protein] Applicant: Wyeth Pharmaceuticals Inc. Tina Khoie, M.D., M.P.H FDA/CBER/OVRR/DVRPA November 18, 2009. Presentation Outline.
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Antiplatelet Therapy for Secondary Prevention in the First Year Following an Acute Coronary Syndrome. Canadian Cardiovascular Society Antiplatelet Guidelines.
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Evaluation of Ranolazine in Patients with Type 2 Diabetes Mellitus and Chronic Stable Angina Results from the TERISA Randomized Clinical Trial.
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Selection of D in Clinical Trials of Antimicrobial Therapy - Acute Exacerbation of Chronic Bronchitis. Susan D. Thompson, M.D. February 19, 2002. Acute Exacerbation of Chronic Brochitis (AECB) - Outline. Definition and scope of the problem Selection of D for AECB trials
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Anne Lingford-Hughes Professor of Addiction Biology, Imperial College. Hon Consultant CNWL NHS Foundation Trust. The future of pharmacological treatment. What substances and when?. What Nicotine Alcohol Cannabis Opiates Stimulants Cocaine Methamphetamine Amphetamine Ecstasy
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Artesunate Rectal Capsules. For the initial management of acute malaria in patients who cannot take medication by mouth and for whom parenteral treatment is not available
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Behandeling van sinustrombose. plaatje. P : patient met cerebrale sinustrombose I : antistollings therapie C : geen antistolling / placebo O : functionele outcome / mortaliteit. Anticoagulation for cerebral sinus thrombosis Stam/de Bruijn/DeVeber Cochrane Library.
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Mother and Child Health: Research Methods. G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press . Basic Design of Clinical Trials. Cured. Same. Treatment. Sample. Randomise. Blinding. Placebo. Cured. Same. Subjects. Blocking. Variations in Basic Design -1.
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Atorvastatin in Type 2 diabetics on dialysis: 4D Study. 1255 T2DM patients on dialysis for 8.3 mo; 29% with prior MI or revascularization or CHD; 35% CHF; 45% PAD Baseline lipids: LDL-C 3.2 mmol /L;TG 3.0 mmol/L Atorva 20mg vs Pbo x 4 yrs; ? LDL-C: 1 mmol/L. 60.
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0. 6. 12. 24. 30. 36. 18. Kaplan-Meier Curve of Time to Primary End Point. Pioglitazone (514 events) Placebo (572 events). Proportion of Events (%). HR = 0.90 (95% CI 0.80-1.02) p = 0.095. Time from Randomization (months). No. at Risk. Pioglitazone Placebo. 2488 2530. 2373 2413.
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