'Protein structure' diaporamas de présentation

21 st Century = Biotech Century. Completion of human genome High-throughput microarray and similar devices Cloning Genetic engineering Computational power. Everyone is moving towards Biotech. Explosive growth of biological data.

A. An overview of molecular biology. Read Human Molecular Genetic Ch. 1 A.1. Background A.2. Macromolecules A.3. DNA structure A.4. RNA transcription and Gene Expression A.5. RNA processing A.5.1. Splicing A.5.2. RNA Capping

Protein structure Visualization Molecular Story. Review “Central Dogma”: Sequence  Structure  function Sequence based analysis Structure based analysis Gene Sequence Protein Structure Protein Function

Proteins: Their Structure and Biological Functions. Biological Functions of Proteins. Proteins are the agents of biological function Enzymes - Ribonuclease Regulatory proteins - Insulin, PCNA Transport proteins - Hemoglobin Structural proteins - Collagen

Molecular Modeling and Drug Discovery. Judith Klein-Seetharaman Assistant Professor Department of Pharmacology University of Pittsburgh School of Medicine and School of Computer Science Carnegie Mellon University USA. Background. View of living organisms as molecular circuitry:

Biochemistry. Organic Chemistry. All living things are mostly composed of 4 elements: H, O, N, C “honk” Compounds are broken down into 2 general categories: Inorganic Compounds : Do not contain carbon Organic compounds Contain significant amounts of carbon.

Host-Pathogen Interaction. Sites of microbial infection. Mouth. Conjunctiva of eye. Skin. Scratch, injury. Pores, hair Follicles, Sweat glands. Lung. Insect bite. Digestive tract. Urogenital tract. Pathogenic microbes. Normal non-pathogenic microflora. Anus.

Chapter 23. Image Bank. Preview. Types of Carbohydrates Carbohydrates Structures of Carbohydrates Lipids Structures of Amino Acids Proteins Levels of Protein Structure Structures and Roles of Several Amino Acids Enzyme Mechanism Activation Energy With and Without an Enzyme

Organic Compounds. It used to be thought that only living things could synthesize the complicated carbon compounds found in cells German chemists in the 1800’s learned how to do this in the lab, showing that “organic” compounds can be created by non-organic means.

Introduction and Fundamentals of Protein Structure. Proteins are polypeptides, which are made up of many amino acids linked together as a linear chain

Genetic Algorithm in Protein Structure Comparison. Chen Jinxiu,Feng yuan,Lan Man, Li Haiquan,Li Quan, Ren li'an Laboratories for Information Technology. Outline. Background: Protein Structure Comparison and Genetic Algorithm Overview of GA in structure comparison

Important Biological Macromolecules. Biology for Majors. Proteins. Proteins  are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules.

Lecture 6. Protein Structure and Properties. Torsion Angles. When both peptide bonds are in trans conformation: F = -180 Y = 180. Globular Proteins. Exist as compact, roughly spherical molecules Highly Solvated. Superseconday Structure.

Genomics & Proteomics Based Drug DISCOVERY. Dr. Basavaraj K. Nanjwade M.Pharm., Ph. D Associate Professor Department of Pharmaceutics KLE University BELGAUM – 590010. Genomics.

Protein structure prediction. Protein folds. Fold definition: two folds are similar if they have a similar arrangement of SSEs (architecture) and connectivity (topology). Sometimes a few SSEs may be missing.

Protein structure prediction. Siddhartha Jain. Amino acid structure. 4 levels of protein structure. Protein secondary structural motifs. Alpha helices Each AA corresponds to 100 degree turn in helix and translation of 1.5 angstroms. Protein secondary structural motifs. Beta sheets

Structural Bioinformatics. R. Sowdhamini National Centre for Biological Sciences Tata Institute of Fundamental Research Bangalore, INDIA. 1. Prediction of Secondary Structure and Tertiary Interactions in Proteins. How to predict  -sheets?. Problems in prediction: Sequentially distant

Virtual Organizations: Building Interdisciplinary Collaborations. Dan Reed reed@renci.org Chancellor’s Eminent Professor Vice Chancellor for IT University of North Carolina at Chapel Hill Director, Renaissance Computing Institute. Acknowledgments. Funding agencies NIH

Homayoun Valafar Department of Computer Science and Engineering, USC. Amino Acids, Polypeptides and Proteins. Protein. Proteins are functional elements of a cell Proteins are made of 20 “ amino acid ” subunits Proteins fold to create a their own characteristic fold (three dimensional shape).

Protein Structure 101. Alexey Onufriev, Virginia Tech www.cs.vt.edu/~onufriev. Proteins play key roles in a living system. Three (out of many many) examples of protein functions Catalysis: Almost all chemical reactions in a living cell are catalyzed by protein enzymes.