'Regulatory motif' diaporamas de présentation

Motif Finding

Motif Finding. PSSMs Expectation Maximization Gibbs Sampling. Complexity of Transcription. A matrix describing a a set of sites. A 14 16 4 0 1 19 20 1 4 13 4 4 13 12 3 C 3 0 0 0 0 0 0 0 7 3 1 0 3 1 12 G 4 3 17 0 0 2 0 0 9 1 3 0 5 2 2

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Motif discovery and Phylogenetic trees

Motif discovery and Phylogenetic trees. Motif Discovery Challenges. How to recognize a known regulatory motif in genome scale? Can we discover new motifs within upstream sequences of genes?. Scenario 1 : Binding motif is known. Building a PSSM for short motifs.

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From Pairwise to Multiple Alignment

From Pairwise to Multiple Alignment. WHATS TODAY?. Multiple Sequence Alignment- CLUSTAL MOTIF search. M ultiple S equence A lignment MSA. VTIS C TGSSSNIGAG-NHVK W YQQLPG VTIS C TGTSSNIGS--ITVN W YQQLPG LRLS C SSSGFIFSS--YAMY W VRQAPG LSLT C TVSGTSFDD--YYST W VRQPPG

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Sequence Motifs

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Regulatory Motifs

Regulatory Motifs. Contents Biology of regulatory motifs Experimental discovery Computational discovery PSSM MEME. What Makes Regulatory Motifs Important? The DNA sequence in every cell of an individual is identical.

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Goal

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