'Senescent cells' diaporamas de présentation

Practical Hematology Blood Loss Anemia

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MCB 135K: Discussion

MCB 135K: Discussion. February 7, 2005 GSI: Laura Epstein. Topics. Epidemiology of Aging Telomeres. EPIDEMIOLOGY OF AGING. THE STUDY OF THE AGE-RELATED DISTRIBUTION AND CAUSES OF DISEASE, DISABILITY, AND MORTALITY IN HUMAN POPULATIONS. EPIDEMIOLOGY OF AGING. WHY IMPORTANT?

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Wound Care Interventions

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EGF Skincare Serum

EGF Skincare Serum. Beauty-care Section of Product Management Dept. The progress of modern skin-care product. ?. Generation ?-Gene Regeneration Products Nourishing skin and anti-aging on the level of cells & molecules. EGF the representative of fourth generation.

717 views • 33 slides

Supplement 12-1

Supplement 12-1. What is the Relationship Between Replicative Cell Senescence & Functional Tissue Senescence. Addition to Biology of Aging 3e by Robert Arking. Relationship between stress & telomeres? von Ziglincki psychological stress alters telomere length

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Cellular Senescence What is it? What causes it? Why is it important (cancer and aging)?

Cellular Senescence What is it? What causes it? Why is it important (cancer and aging)?. Cellular Senescence What is it? Response of normal cells to potentially cancer-causing events The senescence response is an anti-cancer mechanisms that prevents

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GSIG Journal Club March 15, 2012

GSIG Journal Club March 15, 2012. Hepatocellular carcinoma (HCC) Malignant adult tumor with multiple suspected origins- hepatocyte, biliary , or adult progenitor cells, occurs at age 50+, incidence of ~5/100,000 (US) and rising (HCV)

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Andrew Rosenzweig, MD Lab Meeting 2.26.08

Development and Validation of an In Vitro Model for Osteoblast Aging: Beta-galactosidase and Acridine Orange. Andrew Rosenzweig, MD Lab Meeting 2.26.08. Goals.

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Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders

1 0 N O V E M B E R 2 0 1 1 | VO L 4 7 9 | N AT U R E | 2 3 3. Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders Darren J. Baker1,2,3, TobiasWijshake1,4, Tamar Tchkonia3, Nathan K. LeBrasseur3,5, Bennett G. Childs1, Bart van de Sluis4,

445 views • 15 slides

Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders

1 0 N O V E M B E R 2 0 1 1 | VO L 4 7 9 | N AT U R E | 2 3 3. Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders Darren J. Baker1,2,3, TobiasWijshake1,4, Tamar Tchkonia3, Nathan K. LeBrasseur3,5, Bennett G. Childs1, Bart van de Sluis4,

188 views • 15 slides

Section 4 Cellular Aging

Section 4 Cellular Aging. A number of cellular functions decline progressively with age. Mechanism. A progressive accumulation of sublethal injury that compromises cellular function and may lead to cell death, or at least to diminished capacity of cells to respond to injury. . Mechanism.

384 views • 6 slides

A combination of biomarkers to identify senescent cells

A combination of biomarkers to identify senescent cells. Senescence associated Beta Galactosidase activity (SA-bgal) is increased during replicative aging of cells and other conditions. Nucleoli number can accurately distinguish between young and old cells

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Cell number

70. 71. 19. 25. 10. 5. Cell number. Cell number. Cell number. Cell number. PI. PI. PI. PI. 67. 40. 20. 13. 38. 22. proliferating A549. senescent A549. a. b. proliferating MCF-7. senescent MCF-7. c. d.

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p53

H- Ras p53. Cancer in nude mice. 12. 6. 10. p53. p53. 8. 7. 5. 9. 11. p53. hTERT. 1. 3. Senescent cells. Primary human fibroblasts. 4. p53. 40. 140. 215. 355. 490. PDLs :. 9.WI-38 T fast 490 pdl. 9.WI-38 T fast 490 pdl. 9.WI-38 T fast 490 pdl.

220 views • 1 slides