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SIRT6 and the disease of aging

SIRT6 and the disease of aging. Mark Devries. Outline . Background Sirtuin biology SIRT6 role in aging Results Phylogeny Protein domains Phenotype DNA motifs Possible protein modifications Chemical activators Protein interactions Future directions.

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Supplementary Fig S3

A. MCF-7EpiR. MCF-7TaxR. siControl. siSIRT6. siControl. siSIRT6. Paclitaxel ( h ):. Epirubicin ( h ). 0. 24. 48. 0. 24. 48. 0. 48. 72. 0. 48. 72. SIRT6. SIRT6. FOXO3a. FOXO3a. p27Kip1. p27Kip1. H3K9ac. Ac-p53. H3K56ac. p53. H3K9Ac. Ac-α-TUBULIN. H3K56Ac.

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