'Somatic hypermutation' diaporamas de présentation

Discovery Research via in vivo Evolution

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Chapter 5 Organization and Expression of Ig Genes

Chapter 5 Organization and Expression of Ig Genes. Oct 26 & 31, 2006. ???????? : ??????????? ?????? (rearrangement) ??? ?????? (diversity) ??????? ?????????????????? ????? (class) ????? - class switching. Central Feature of Ab Molecules: Vast diversity of Ab specificities

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T Cell Receptor

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Dr. Kathy McCoy kmccoy@vcu.edu

Dr. Kathy McCoy kmccoy@vcu.edu. Antigen receptors. Isotypes. Precursor T cells acquire TCR expression in the thymus. T cells do not change their TCR - No isotype switching. T Cell Receptors. Associate with other molecules: CD3 complex for both isotypes CD4 or CD8 for ??? TCR

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Adaptive immune system (What we and other vertebrates have in addition to an innate immune system)

Adaptive immune system (What we and other vertebrates have in addition to an innate immune system). Makes specific immune response to a pathogen (1790s): Jenner showed that exposure to cowpox protected against infection by a related virus: smallpox

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? Immunology?Lecture 3 ? B Cell and Antibody

? Immunology?Lecture 3 ? B Cell and Antibody. Feng Zhang ( Ph.D ) Office ? Biological Building Room 402 Email ? zhangfeng@imau.edu.cn. 3.1 B Cell. Born in the bone marrow 1 billion B cell per day per guy

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Organization and Expression of Immunoglobulin Genes

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Heavy Chain Rearrangement

Heavy Chain Rearrangement. The B cell receptor is made up of two kinds of proteins, the heavy chain ( Hc ) and the light chain ( Lc )., Each of these proteins is encoded by genes that are assembled from gene segments.

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Structure of T Cell Receptor

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