Substitution probabilities - PowerPoint PPT Presentation

Cladogram Building - 1

Cladogram Building - 1. How complex is this problem anyway ?. NP-complete: Time needed to find solution in-creases exponentially with size of problem -&gt; t = c n. Computational Complexity. How do we proceed ? What about the quality of the solution ? Optimality criterion

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Model Selection Anders Gorm Pedersen Molecular Evolution Group

Model Selection Anders Gorm Pedersen Molecular Evolution Group Center for Biological Sequence Analysis Technical University of Denmark (DTU). The maximum likelihood approach. Likelihood = Probability (Data | Model) Maximum likelihood:

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