'Tag snps' diaporamas de présentation

The Questions

The Questions. Why study haplotypes? How can haplotypes be inferred? What are haplotype blocks? How can haplotype information be used to test associations with disease phenotypes? How shall we select a subset of informative SNPs for large-scale typing?

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Overview Molecular Newborn Screening

Overview Molecular Newborn Screening. Michele Caggana, Sc.D. Director, Newborn Screening Program New York State Department of Health Wadsworth Center. Wadsworth Center. ORNL. Human Genome Project. Proposed by Victor McKusick in 1968 DOE and NIH, 15 years, 30 billion dollars

846 views • 62 slides

A Data Compression Problem

625 views • 54 slides

Introduction to SNP and Haplotype Analysis

Introduction to SNP and Haplotype Analysis. Yao-Ting Huang. Kun-Mao Chao. Algorithms and Computational Biology Lab, Department of Computer Science & Information Engineering, National Taiwan University, Taiwan. Genetic Variations.

551 views • 54 slides

Introduction to SNP and Haplotype Analysis

Introduction to SNP and Haplotype Analysis. Yao-Ting Huang. Kun-Mao Chao. Algorithms and Computational Biology Lab, Department of Computer Science & Information Engineering, National Taiwan University, Taiwan. Genetic Variations.

675 views • 52 slides

Computational problems involving Single Nucleotide Polymorphisms

Computational problems involving Single Nucleotide Polymorphisms. Pritam Chanda. Agenda. Biological background SNP representation Tag SNP selection Haplotype analysis SNP-disease association study Discussion. Central Dogma. A cell and its chromosomes. DNA structure.

742 views • 47 slides

A New Model of Multi-Marker Correlation for Genome-Wide Tag SNP Selection

A New Model of Multi-Marker Correlation for Genome-Wide Tag SNP Selection. Wei-Bung Wang Tao Jiang. Introduction. Outline. Introduction Problem Related Work Our Approach Result. Introduction. C T T A G C T T. 94%. C T T A G T T T. 6%. SNP. Single Nucleotide Polymorphism.

498 views • 39 slides

A New Model of Multi-Marker Correlation for Genome-Wide Tag SNP Selection

A New Model of Multi-Marker Correlation for Genome-Wide Tag SNP Selection. Wei-Bung Wang Tao Jiang. Introduction. Outline. Introduction Problem Related Work Our Approach Result. Introduction. C T T A G C T T. 94%. C T T A G T T T. 6%. SNP. Single Nucleotide Polymorphism.

413 views • 39 slides

Pattern Identification in a Haplotype Block

Pattern Identification in a Haplotype Block. Kun-Mao Chao ( ??? ) Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University, Taiwan http://www.csie.ntu.edu.tw/~kmchao. Genetic Variations.

549 views • 35 slides

Speaker: Yao-Ting Huang Advisor: Kuan-Mao Chao

Dynamic Programming Algorithms for Haplotype Block Partitioning: Applications to Human Chromosome 21 Haplotype Data. Speaker: Yao-Ting Huang Advisor: Kuan-Mao Chao. National Taiwan University Department of Computer Science & Information Engineering Algorithms and Computational Biology Lab.

470 views • 33 slides

Combinatorial Algorithms for Maximum Likelihood Tag SNP Selection and Haplotype Inference

Combinatorial Algorithms for Maximum Likelihood Tag SNP Selection and Haplotype Inference. Ion Mandoiu University of Connecticut CS&E Department. Outline. Biological background Maximum likelihood tag SNP selection Maximum likelihood population haplotyping Ongoing and future work.

388 views • 28 slides

Fatchiyah, PhD Dept Biology UB Fatchiyah.lecture.ub.ac.id

Fatchiyah, PhD Dept Biology UB Fatchiyah.lecture.ub.ac.id. Why do we care about genetic variations?. 1. Genetic variations underlie phenotypic differences among different individuals.

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Clustering and optimization in genetic data: the problem of Tag-SNPs selection

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Informative SNP Selection Based on Multiple Linear Regression

Informative SNP Selection Based on Multiple Linear Regression. Jingwu He Alex Zelikovsky. Outline. SNPs, haplotypes, and genotypes Tagging problem formulation Tagging based on multiple linear regression Experimental results. Human Genome. Length of Human Genome (DNA)

359 views • 18 slides

Linear Reduction Method for Tag SNPs Selection

Linear Reduction Method for Tag SNPs Selection. Jingwu He Alex Zelikovsky. Outline. SNPs , haplotypes and genotypes Haplotype tagging problem Linear reduction method for tagging Maximizing tagging separability Conclusions & future work. Outline.

353 views • 18 slides

Human Genetics

Human Genetics. Linkage. The observation that two genes are not transmitted independently. Why? Two genes physically near each other on a chromosome will not assort randomly in meiosis. Linkage. Linkage. Tightly linked: two types of gametes in this case - PL and pl. Unlinked:

346 views • 18 slides

Linear Reduction Method for Tag SNPs Selection

Linear Reduction Method for Tag SNPs Selection. Jingwu He Alex Zelikovsky. Outline. SNPs , haplotypes and genotypes Haplotype tagging problem Linear reduction method for tagging Maximizing tagging separability Conclusions & future work. Outline.

186 views • 18 slides

Encode variation analysis

Encode variation analysis. Analysis goals. Quantify genetic variation in ENCODE regions Detect selective constraint in ENCODE features Develop rules for interpretation of functional variation Motivate experiments to test functional variation. Data. Encode SNPs (HapMap resequencing)

304 views • 15 slides

Optimal Tag SNP Selection for Haplotype Reconstruction

Optimal Tag SNP Selection for Haplotype Reconstruction. Jin Jun and Ion Mandoiu Computer Science & Engineering Department University of Connecticut. Approaches to Phasing. Motivation and Contributions.

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The International Consortium. The International HapMap Project. Nature. 426, 789-796 (2003)

The International Consortium. The International HapMap Project. Nature. 426, 789-796 (2003). The International HapMap Project. Launched October 29, 2002 Major initiative to map human genetic variation based on haplotype patterns.

309 views • 11 slides