'Wide association study' diaporamas de présentation

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Human Genetic Variation

Human Genetic Variation. Genetics of Complex Diseases. The Human Genome Project - Goals. Determine the sequences of the 3 billion base pairs that make up human DNA . The Human Genome Project - Goals. Determine the sequences of the 3 billion chemical base pairs that make up human DNA

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Host Genetics of HCV: Relevance for the study of HCV in Africa

Host Genetics of HCV: Relevance for the study of HCV in Africa. Thomas J. Urban, PharmD , PhD Center for Human Genome Variation Duke University Medical Center Durham, NC, USA. Natural History of HCV Infection. 100 patients. Resolve 20-50 %. Chronic Hepatitis 50-80 %. WHY????.

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positional cloning of human disease genes: a reversal of scientific priorities

positional cloning of human disease genes: a reversal of scientific priorities. Prior To 1989. disease phenotype. hypothesize function. clone the gene. chromosomal position. functional cloning. AFTER 1989. disease phenotype. chromosomal position. clone the gene. hypothesize function.

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Genome-wide association studies

Genome-wide association studies. BNFO 602 Roshan. Application of SNPs: association with disease. Experimental design to detect cancer associated SNPs: Pick random humans with and without cancer (say breast cancer) Perform SNP genotyping Look for associated SNPs

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Tracing Human Evolution with Genetics

Tracing Human Evolution with Genetics SELECTION June 9-17, 2007 SNPs Single Nucleotide Polymorphisms May or may not be in coding regions May or may not cause phenotypic changes Frequency of SNP distribution varies Seq 1 ATCGG AT C CA TG T AT CGATT Seq 2 AT G GG ATGCA TG T AT CGATT

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