'Wnt signaling' diaporamas de présentation

Signaling Pathways that Depend on Regulated Proteolysis

Signaling Pathways that Depend on Regulated Proteolysis. 7 May 2007. Identified through genetic studies in drosophila. Highly conserved in evolution and are very important in animal development. Wnt Notch Hedgehog NF ?B. Wnts.

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Targeting Wnt S ignaling in C olorectal C ancer

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Diabetes Mellitus Type II

Diabetes Mellitus Type II. Beta Cell Failure in DM T2. signaling pathways implicated in ? -cell failure. Controls organismal growth and differentiation. Wnt Signaling Pathway. Wnt signalling Pathway and DM T2.

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The Wnt Signaling Pathway

The Wnt Signaling Pathway. Jennifer Slade B.Sc. (Hon) M.Sc. Candidate. Introduction Overview of Wnt signaling Components of Wnt signaling Wnt proteins Palmitoylation Transport Wnt receptors Interactions with extracellular proteins How they signal. Cytoplasmic Signaling cascade

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Colon cancer is the second leading cause of cancer deaths in the U.S.

Colon cancer is the second leading cause of cancer deaths in the U.S. Polyps, the first stage In tumor development. http://www.clevelandclinic.org/registries/inherited/fap.htm. Familial Adenomatous Polyposis (FAP). Adenomatous Polyposis Coli (APC). tumor suppressor.

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10.23 The role of Wnt pathway proteins in dorsal-ventral axis specification

10.20 Summary of experiments by Nieuwkoop and by Nakamura and Takasaki, showing mesodermal induction by vegetal endoderm (Part 1). 10.20 Summary of experiments by Nieuwkoop and by Nakamura and Takasaki, showing mesodermal induction by vegetal endoderm (Part 2).

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The State of the Art in Osteoporosis: Advancing Care Through Improved Understanding

The State of the Art in Osteoporosis: Advancing Care Through Improved Understanding. Prevalence of Osteoporosis. Consequences of Fractures. Economic Toll of Fractures. Functions of Wnt Signaling. Osteocytes. Osteocytes Within the Bone Matrix. Osteoclasts. Abbreviations.

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Downregulation of Wnt/?-catenin signaling causes degeneration of hippocampal neurons in vivo

Downregulation of Wnt/?-catenin signaling causes degeneration of hippocampal neurons in vivo. Introduction. Wnt binds to Frizzled or other receptors such as LRP5/6 Downstream signaling cascade including Dvl, GSK-3?, Axin

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Downregulation of Wnt/?-catenin signaling causes degeneration of hippocampal neurons in vivo

Downregulation of Wnt/?-catenin signaling causes degeneration of hippocampal neurons in vivo. Introduction. Wnt binds to Frizzled or other receptors such as LRP5/6 Downstream signaling cascade including Dvl, GSK-3?, Axin

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Smad7-induced b -catenin degradation alters epidermal appendage development

Smad7-induced b -catenin degradation alters epidermal appendage development. Han, G. et al., 2006, Dev Cell. Diagrammatic Depiction of the Hair Follicle Stem Cell Niche and the Cutaneous Lineages Deriving from the Bulge Stem Cells Adapted from Alonso and Fuchs, 2003.

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The role of the SRY gene in determing sex.

The role of the SRY gene in determing sex. Ahmed Mahmoud 10-29-2009. What makes a male or female?. In mammals, gonadal development is determined by the sex chromosomes. XX usually constitutes female XY constitutes male How ever, some males have XX Some females have XY Why is this?.

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Frodo Links Dishevelled to the p120-Catenin/Kaiso Pathway: Distinct

Frodo Links Dishevelled to the p120-Catenin/Kaiso Pathway: Distinct Catenin Subfamilies Promote Wnt Signals. Park et al . Dev Cell . (2006). Linear structural representation of catenin family proteins. McCrea et al. Biochim Biophys Acta. (2006).

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HIC1 attenuates Wnt signaling by recruitment TCF-4 and ? -catenin to the nuclear bodies

HIC1 attenuates Wnt signaling by recruitment TCF-4 and ? -catenin to the nuclear bodies. EMBO Journal (2006). Wnt signaling in the nucleus. Wnt Off. Wnt On. Wnt Off (negative feedback). HDAC. Groucho. (Xi He et al , Development , 2006). ? TCF/LEF-1.

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Yu A. et al, Developmental cell (2007)

Association of Dishevelled with the Clathrin AP-2 Adaptor Is Required for Frizzled Endocytosis and Planar Cell Polarity Signaling. Yu A. et al, Developmental cell (2007). Wnt signaling and Endocytosis.

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Developmental stage-specific biphasic roles of Wnt signaling

Developmental stage-specific biphasic roles of Wnt signaling. in cardiomyogenesis and hematopoiesis. (Atsuhiko T. Naito et al, 2006, Development ). Wnt signalings in embryonic development. Zygotically expressed wnt8 may be involved in specifying or patterning ventral mesoderm.

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Aberrant Wnt / b -catenin signaling can induce

Aberrant Wnt / b -catenin signaling can induce. chromosomal instability in colon cancer. Behrens. J et al , PNAS, 2006. Introduction. ? The hallmarks of colon tumors. - APC mutation. Mutations in APC are the most frequent events in colon tumors. (Powell, S.M et al , Nature , 1992).

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The Wnt/-Catenin ? Pitx2 Pathway Controls the Turnover of Pitx2 and Other Unstable mRNAs

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No Wnt signaling

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Introduction

Genetic variants in Wnt signaling pathway predict gender and tumor location dependent survival in metastatic colorectal cancer (mCRC) patients(pts) treated with first-line FOLFIRI and Bevacizumab(FOLFIRI/BEV)

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