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Hypothalamic-Pituitary-Adrenal Axis

Hypothalamic-Pituitary-Adrenal Axis. Natthaya Duanghaklang. http://en.wikipedia.org/wiki/File:Basic_HPA_Axis.jpeg. Negative feedback. Corticotropin-releasing hormone (CRH). peptide hormone and neurotransmitter involved in the stress response

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Hypothalamic-Pituitary-Adrenal Axis

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  1. Hypothalamic-Pituitary-Adrenal Axis NatthayaDuanghaklang

  2. http://en.wikipedia.org/wiki/File:Basic_HPA_Axis.jpeg

  3. Negative feedback

  4. Corticotropin-releasing hormone (CRH) • peptide hormone and neurotransmitter involved in the stress response • stimulates the synthesis and the secretion of ACTH in the corticotropin-producing cells (corticotrophs) of the anterior pituitary gland

  5. Adrenocorticotropic hormone (ACTH) • polypeptide tropic hormone produced and secreted by the anterior pituitary gland (corticotropic cell) • component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress • stimulates secretion of glucocorticoid steroid hormones from adrenal cortex

  6. Cortisol • steroid hormone, produced by the zona fasciculata of the adrenal cortex. • released in response to stress and a low level of blood glucocorticoids. • The release of cortisol is controlled by CRH and ACTH

  7. Pathway of Cortisol

  8. THANK YOU FOR YOUR ATTENTION

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