1. Hypothalamic-Pituitary-Adrenal Axis NatthayaDuanghaklang

2. http://en.wikipedia.org/wiki/File:Basic_HPA_Axis.jpeg

3. Negative feedback

4. Corticotropin-releasing hormone (CRH) • peptide hormone and neurotransmitter involved in the stress response • stimulates the synthesis and the secretion of ACTH in the corticotropin-producing cells (corticotrophs) of the anterior pituitary gland

5. Adrenocorticotropic hormone (ACTH) • polypeptide tropic hormone produced and secreted by the anterior pituitary gland (corticotropic cell) • component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress • stimulates secretion of glucocorticoid steroid hormones from adrenal cortex

6. Cortisol • steroid hormone, produced by the zona fasciculata of the adrenal cortex. • released in response to stress and a low level of blood glucocorticoids. • The release of cortisol is controlled by CRH and ACTH

7. Pathway of Cortisol

8. THANK YOU FOR YOUR ATTENTION