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Pills of the Future By Richard Perry

Pills of the Future By Richard Perry. Nanoparticles That Can Be Taken Orally. Researchers from MIT have developed a new type of nanoparticle that can be delivered orally and absorbed through the digestive tract, allowing patients to simply take a pill instead of receiving injections. Benefits.

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Pills of the Future By Richard Perry

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  1. Pills of the Future By Richard Perry

  2. Nanoparticles That Can Be Taken Orally • Researchers from MIT have developed a new type of nanoparticle that can be delivered orally and absorbed through the digestive tract, allowing patients to simply take a pill instead of receiving injections.

  3. Benefits • This type of drug delivery could be especially useful in developing new treatments for conditions such as high cholesterol or arthritis. • Patients with those diseases would be much more likely to take pills regularly than to make frequent visits to a doctor's office to receive nanoparticle injections

  4. Chemotherapy • Several types of nanoparticles carrying chemotherapy drugs or short interfering RNA, (ribonucleic acid, a nucleic acid) which can turn off selected genes, are now in clinical trials to treat cancer and other diseases. These particles exploit the fact that tumors and other diseased tissues are surrounded by leaky blood vessels. After the particles are injected into patients, they seep through those leaky vessels and release their payload at the tumor site.

  5. No more injections • For nanoparticles to be taken orally, they need to be able to get through the intestinal lining. • The key challenge is how to make a nanoparticle get through this barrier of cells thats like a brick wall.

  6. Building nanoparticles that can selectively break through the barrier, the researchers took advantage of previous work that revealed how babies absorb antibodies from their mothers' milk, boosting their own immune defenses. Those antibodies grab onto a cell surface receptor called the FcRN, granting them access through the cells of the intestinal lining into adjacent blood vessels.

  7. Coating the Nanoparticles • The researchers coated their nanoparticles with Fc proteins the part of the antibody that binds to the FcRN receptor • After the particles are ingested, the Fc proteins grab on to the FcRN in the intestinal lining and gain entry, bringing the entire nanoparticle along with them.

  8. sources • http://www.sciencedaily.com/ • Massachusetts Institute of Technology. "Pills of the future: Nanoparticles; Researchers design drug-carrying nanoparticles that can be taken orally." ScienceDaily, 27 Nov. 2013. Web. 4 Dec. 2013.

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