1 / 10

Glycine Free Amino Acid or Integrated into Proteins Precursor: Serine Serine hydroxy-

Glycine Free Amino Acid or Integrated into Proteins Precursor: Serine Serine hydroxy- methylase (folate dependent) Glycine. Presynapse Serine

shayna
Télécharger la présentation

Glycine Free Amino Acid or Integrated into Proteins Precursor: Serine Serine hydroxy-

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Glycine Free Amino Acid or Integrated into Proteins Precursor: Serine Serine hydroxy- methylase (folate dependent) Glycine

  2. Presynapse Serine Glycine (sotrage ???) ------------------------------------------------------------------------ Synaptic cleftNa-dependent transporter ------------------------------------------------------------------------ Glycine A-receptor Postsynapse ionotropic Cl- channel, inhibitory Glycine B-receptor = Gly binding site of the NMDA receptor

  3. Release inhibitor: Tetanus toxin Agonists at the Gly A-R Gly, beta-alanine, taurine Antagonists strychnine picrotoxin (Cl- channel blocker)

  4. Agonists at the Gly B-R = Gly binding site of NMDA-R Gly, D-serine, HA 966 Gly transporter inhibitors Under development Antagonists Dichlorokynurenate MNQX

  5. Physiology Gly A-R Presynaptic inhibition: Spinal cord: Feed-back-inhibition of motoneuron activity Gating Habituation Inhibitory on brain stem activity on ARAS In the retina Pathophysiology Reduced activity: muscular convulsions (for example strychnin poisening) Enhanced activity: inhibition of motoneurons inhibition of ARAS (narcosis)

  6. Glycinerig Renshaw neuron

  7. Anatomy Glycin-A-receptor Spinal cord: Renshaw-inhibition (only in vertebrates) Supraspinal: brain stem retina Glycin-B-receptor Corresponds to the distribution of NMDA-receptors

  8. Physiology of Gly B-Receptor Allosteric modulation of the NMDA receptor Pathophysiology Enhanced activity: Enhances affinity for Glutamate and channel opening frequency. Facilitates learning Anti-schizophrenic ??? Reduced activity: Some simailarities with weak NMDA-R-antagonists Psycic and motor activation (in Alzheimer‘s disease Gly-R density is reduced)

More Related