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All about Antithymocyte globulin

ATGAM is indicated for any patient in whom reduction of peripheral T-lymphocyte function as measured by rosette-forming cell assay could be desirable.

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All about Antithymocyte globulin

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  1. All about Antithymocyte globulin ATGAM is indicated for any patient in whom reduction of peripheral T-lymphocyte function as measured by rosette-forming cell assay could be desirable. It is prescribed at the time of kidney rejection and can be used with other therapies in order to delay the onset of a first rejection episode. It can also be prescribed for other complications such as allografts, aplastic anemia, bone marrow transplantation) The antithymocyte globulin is an infusion of horse or rabbit-derived antibodies against the human T cells.

  2. How you have ATGAM? ATGAM should always be prepared and given to you by a healthcare professional. Before the first infusion of ATGAM, your doctor may perform the skin testing. The recommended daily dose of atgam injection for renal-allograft patients is 10 to 30 mg/kg of body weight. The recommended daily dose for delaying the onset of allograft rejection is 15 mg/kg for 2 weeks, then every other day for 2 weeks for a total of 21 doses in 28 days. The initial dose is administered within the 24 hours prior to or following transplant. The recommended daily dose for treatment of rejection is 10-15 mg/kg for 2 weeks.

  3. Mechanism of Action ATGAM specifically acts in order to reduce the certain cells within your immune system which are more likely to attack on transplanted organs. Your healthcare provider may also prescribe atg injection for another purpose.

  4. Side Effects of ATGAM The possible side effects due to atgam are listed as follows: • Chills  • Fever  • Leukopenia • Thrombocytopenia  • Skin reactions • Arthralgia (joint pain)  • Chest pain • Back pain  • Diarrhea • Shortness of breath  • Headache

  5. What may interact with ATGAM? Drugs that may interact with this medication include: • Live vaccines should not be administered when you are about to receive, receiving, or after treatment with rabbit antithymocyte globulin.  • Do not use this drug together with a dextrose infusion solution, as reduced concentration of salt may cause precipitation. • Avoid using the highly acidic infusion solutions, it may cause possible physical instability over time.  • Dose reduction of corticosteroids and other immunosuppressants may cause previously masked reactions to this drug. Your Healthcare team will monitor you when atg injection is being infused.

  6. What happens in case I overdosed on ATGAM? In case of antithymocyte globulin drug overdose, contact a health care practitioner, hospital emergency department, even if there are no symptoms. What happens in case of missed dose? ATGAM is normally administered by a healthcare practitioner in the hospital. If you missed an atgampfizer dose, immediately contact your doctor. Source URL: https://ikrispharma.tumblr.com/post/641903253518499841/all-about-antithymocyte-globulin

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