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Bone Formation and Bone Remodeling

Bone Formation and Bone Remodeling. S.K. Kim November 16, 2009. 46HE (H & E). Intramembranous bone formation of maxilla (flat bone). Nasal cavity. Nasal cavity. Oral cavity. Nasal septum (hyaline cartilage). Tongue. 46M ( Masson or Trichrome).

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Bone Formation and Bone Remodeling

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  1. Bone Formationand Bone Remodeling S.K. Kim November 16, 2009

  2. 46HE (H & E) Intramembranous bone formation of maxilla (flat bone) Nasal cavity Nasal cavity Oral cavity Nasal septum (hyaline cartilage) Tongue

  3. 46M (Masson or Trichrome) Mandibular bone (flat) formation: Intramembranous ossification Rotate 180o Tongue (skeletal muscle) Forming tooth Forming mandibular bone Meckel’s cartilage (hyaline) Genioglossus muscle (skeletal muscle) Lower jaw

  4. #120-N

  5. #120 Developing face (frontal section) Forming facial (maxillary) bone: Intramembranous ossification Nasal cavity Orbit: eye ball Oral cavity Tongue Nasal septum: (hyaline cartilage)

  6. Intramembranous bone formation. #46-HE; #46-M; #120 Bone trabecula(e) or spicules Periosteum

  7. Bone Cells Osteoid ? #3 ? #1 Periosteum ? #2 Osteoblasts ? #5 Osteoclasts Osteocytes ? #4

  8. 115N (H&E)Sagital section of the palate 115-M (Masson) Rotate 180o Developing tooth Nasal cavity Upper lip Oral cavity Intramembranous, palatal and maxillary bone formation Gingiva (gum)

  9. Trabecular bone before conversion to compact bone #115N

  10. Immature (woven/mottled) bone; #115N Highly cellular: aggregation of osteocytes Basophilic: high concentration of GAGs

  11. #115N Sharpey’s fibers

  12. Beginning of osteon formation; #115N

  13. Growth in diameter of a long bone #48 (H&E) and 48b (Masson) Periosteum

  14. Long bone shaft:growth in diameter #48 (tibia and fibula) Fibula Periosteum (Fibrous) (cellular) Tibia Osteoblasts Osteoid

  15. #110 (finger, H&E) Endochondral Bone formation Epiphysis Metaphysis Diaphysis Epiphyseal plate

  16. Epiphyseal plate and endochondral bone formation #108 (3) Chondrocyte hypertrophy Cartilage calcification (4) Erosion of calicified cartilage and bone deposition (ossification) (5) (1) Resting cartilage (2) Chondrocyte proliferation Tide mark

  17. Epiphyseal plate and endochondral bone formation #49

  18. Calcified cartilage core in trabecular bone #49

  19. Bone Remodeling Erosion (resorption) Tunnel

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