1 / 1

Analysis of TCR Recombination and Deletion Events in TCR Alpha and Delta Loci

This study investigates the mechanisms of T cell receptor (TCR) recombination and deletion in the alpha (TCR-alpha) and delta (TCR-delta) loci. We detail the role of variable (V), diversity (D), and joining (J) gene segments involved in TCR assembly, specifically focusing on deletions in the delta locus and recombination in the alpha locus. Utilizing PCR and TREC analysis, we explore the dynamics of gene rearrangements and their implications for T cell development and function.

sidney
Télécharger la présentation

Analysis of TCR Recombination and Deletion Events in TCR Alpha and Delta Loci

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. TCR-alpha TCR-delta TCR-alpha V-a V-d J-d C-d J-a C-a drec Yalpha V-d1 V-d2 C-d V-an-2 V-an-1 V-an J-a1 J-a2 J-a3 PCR Deletion of the d locus V-d1 C-d V-d2 Signal TREC + V-an-2 V-an-1 V-an J-a1 J-a2 J-a3 drec/Yalpha PCR Recombination of the a locus V-an J-a1 Coding TREC + V-an-3 V-an-2 **J-a3 J-a4 V-an-1 J-a2

More Related