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Management of Chronic HBV Infection in 62-Year-Old Man with Liver Biopsy Findings

This case involves a 62-year-old man with chronic Hepatitis B infection (HBsAg+), elevated ALT and AST levels, and a liver biopsy showing F2 fibrosis scarring. He has initiated Lamivudine (LAM) treatment, with HBV DNA measured at 1.63 x 10^5 IU/mL, and is referred for follow-up in 2012. Key laboratory results include bilirubin at 15, platelet count at 101, and INR at 1.2. The ultrasound shows coarse liver and splenomegaly. Considering these factors, the treatment options, further diagnostic testing, and management strategies should be discussed.

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Management of Chronic HBV Infection in 62-Year-Old Man with Liver Biopsy Findings

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  1. CASE 6 • 62 yo man • HBsAg+ HBeAg- anti-HBe+ anti-HCV- anti-HIV- • Liver Biopsy 2002… F2 scarring • LAM initiated…adherent as best you can determine • Referred to you in 2012 for f/u

  2. CASE 6 • ALT 66 AST 90 Bili 15 Plts 101 Albumin 37 INR 1.2 AFP 15 • U/S…coarse liver/splenomegaly (13.6 cm) • OGD...no varices or PHG • HBV DNA 1.63 x 105 IU/mL What would you treat with? Would you do any special testing? How would you follow?

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