1 / 6

Metabolic effects of CO 2

Metabolic effects of CO 2. Alice Skoumalová. Overview of oxidative fuel metabolism:. Carbon dioxide transport:. CO 2 in the blood: 1. as HCO 3 - (ionization of H 2 CO 3 ) 75-85 % 2. as carbamino groups (CO 2 reacts with amino groups of proteins) 10-15 % 3. dissolved CO 2 5-12 %

solomon-burch
Télécharger la présentation

Metabolic effects of CO 2

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Metabolic effects ofCO2 Alice Skoumalová

  2. Overview of oxidative fuel metabolism:

  3. Carbon dioxide transport: CO2 in the blood: 1. as HCO3- (ionization of H2CO3)75-85 % 2. as carbamino groups (CO2 reacts with amino groups of proteins)10-15 % 3. dissolved CO25-12 % Partial pressures air-inspiration air-expiration arterial blood venous blood pO2 (kPa) 21 15,3 12 – 13,3 4,6 - 6 pCO2 (kPa) 0,03 4,4 4,6 – 6 5,3 – 6,6 CO2 + H2O H2CO3 H+ +HCO3- erythrocytes (carbonate dehydratase)

  4. O2 and CO2 transport: Bohr effect (the increase in acidity of hemoglobin as it binds O2, releases H+) Isohydric carriage of CO2(Hb‘s ability to take up H+ with no change in pH through Bohr effect) Chloride shift (the exchange of Cl- and HCO3- between the plasma and the erythrocyte)

  5. Hypercapnia protects against free radical damage duringhypoxia-ischemia: • Stabilization of the iron-transferrin complex • Shift of the oxygen-hemoglobin saturation curve to the right • Effects on metabolism (improve aerobic metabolism, reduced lactate production, ATP generation) • Direct inhibition of the free radicals Perinatal brain hypoxic-ischemic damage Mechanical ventilation Chronic respiratory failure

  6. CO2: protective effect or radical damage ?

More Related