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First, a little cell biology….

First, a little cell biology…. Krebs cycle features and functions …. fig 16-13. making citrate asymmetric. Stereochemistry of isocitrate production. misprint. box 16-3. Stereochemistry of isocitrate production. misprint. box 16-3. Stereochemistry of isocitrate production: corrected.

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First, a little cell biology….

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  1. First, a little cell biology….

  2. Krebs cycle features and functions… fig 16-13

  3. making citrate asymmetric

  4. Stereochemistry of isocitrate production misprint box 16-3

  5. Stereochemistry of isocitrate production misprint box 16-3

  6. Stereochemistry of isocitrate production: corrected correction box 16-3

  7. Stereochemistry of isocitrate production but…. WHY?

  8. Why isn’t this reaction random?

  9. Alexander “Sandy” Ogston Stereochemistry of isocitrate production this result implies enzyme has asymmetric “landing site”

  10. Stereochemistry of isocitrate production this result implies enzyme has asymmetric “landing site” box 16-3

  11. Stereochemistry of isocitrate production box 16-3

  12. Stereochemistry of isocitrate production implies enzyme has asymmetric “landing site” but… box 16-3

  13. CH2-COO- also means the substrate, citrate, was MADE asymmetrically! is this hard to imagine? box 16-3

  14. Citrate synthase… fig 16-8

  15. Krebs cycle and energy revenue fig 16-13

  16. Ask… or txt: 858 914 4945

  17. Krebs cycle and energy revenue table 16-1

  18. NADH FADH2 a molecular antique from the days when before it was a cycle… fig 16-14 a fermentation!

  19. the amphibolic Krebs cycle… fig 16-15

  20. the amphibolic Krebs cycle: anapleurotic reactions fig 16-15

  21. the anaplerotic reactions table 16-2

  22. the anaplerotic reactions table 16-2

  23. an example: pyruvate carboxylase table 16-2

  24. Biotin! activation of CO2 in pyruvate carboxylase fig 16-16

  25. Biotin! activation of CO2 in pyruvate carboxylase fig 16-16

  26. Biotin! activation of CO2 in pyruvate carboxylase fig 16-16

  27. Biotin! activation of CO2 in pyruvate carboxylase fig 16-16

  28. Biotin! activation of CO2 in pyruvate carboxylase fig 16-16

  29. Biotin! activation of CO2 in pyruvate carboxylase fig 16-16

  30. Ask… or txt: 858 914 4945

  31. Regulation of the Krebs cycle at multiple reactions… three big energy drops are regulated fig 16-18

  32. Regulation of the Krebs cycle... three big energy drops are regulated fig 16-18

  33. Regulation of the Krebs cycle... three big energy drops are regulated fig 16-18

  34. Regulation of the Krebs cycle... three big energy drops are regulated fig 16-18

  35. Can you make glucose from fat using Krebs? Fat breakdown produces AcCoA (later…) Krebs cycle converts AcCoA to OAA OAA can be converted to PEP (PEP-CK) PEP is the rate-limiting step for synthesis of glucose (later…) so, why not? every time you put an acetate in two CO2 come out before you get to OAA!

  36. Krebs cycle and carbon revenue enter the glyoxylate cycle fig 16-13

  37. The Glyoxylate Cycle fancy fig 16-20

  38. H Glyoxylate Cycle: an end run around carbon loss simple rh

  39. Glyoxylate cycle: a cell biologist’s view… in plants fig 16-21

  40. Glyoxylate cycle: a cellular biochemist’s view… fig 16-22 (sort of)

  41. Glyoxylate cycle: a cellular biochemist’s view… fig 16-22

  42. Glyoxylate cycle: a cellular biochemist’s view… fig 16-22

  43. Glyoxylate cycle: a cellular biochemist’s view… fig 16-22

  44. GC/KC: branched pathway regulation fig 16-23

  45. GC/KC: branched pathway regulation ATP glucose fig 16-23

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