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Bacterial Targeting for Precision Therapy: iGEM Harvard 2007

The Harvard iGEM team in 2007, including members Ellenor Brown, Stephanie Lo, Alex Pickett, and others, aimed to develop a system for directing bacteria to specific targets, enabling precise therapeutic activity. This innovation is crucial for localized interventions in biological systems or environmental contexts. The project focuses on post-targeting activity and transmembrane signaling, working towards engineering genetic circuits that connect extracellular signals with intracellular responses. Key visions include bacterial targeting through membrane display and activation mechanisms via Lux quorum sensing and Fec signal transduction.

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Bacterial Targeting for Precision Therapy: iGEM Harvard 2007

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  1. Cling-E. coli :Bacteria on target Harvard iGEM 2007 Ellenor Brown Stephanie Lo Alex Pickett Sammy Sambu Kevin Shee Perry Tsai Shaunak Vankudre George Xu

  2. The motivation To develop a system for directing bacteria to a target of interest and effecting downstream activity • Bacterial targeting is necessary for spatially-specific activity in the body or in nature • Post-targeting activity and transmembranesignalling are the next step in engineering genetic circuits that interface extracellular and intracellular environments

  3. The vision:Bacterial targeting via membrane display

  4. The vision:Inter-cellular activation viaLux quorum-sensing

  5. The vision:Intra-cellular activation viaFec signal transduction

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