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Investigating the Role of 14-3-3 Protein in NHE-1 Phosphorylation in Response to Angiotensin II

This study examines the phosphorylation of NHE-1, facilitated by the 14-3-3 protein, upon stimulation with Angiotensin II. Using a quantitative analysis, we present supplementary data demonstrating the effects of varying Angiotensin II concentrations (137.5 and 140 mmol/L) on NHE-1 activation. Our findings highlight the complex involvement of protein interactions in cellular signaling processes and their implications for cardiovascular health. Supplementary Figure 2 illustrates key results, emphasizing the interaction dynamics and phosphorylation status.

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Investigating the Role of 14-3-3 Protein in NHE-1 Phosphorylation in Response to Angiotensin II

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  1. IP: pSer 14-3-3 pNHE-1 pSer 14-3-3   2.0 1.5 NHE-1 phosphorylation (fold) 1.0 0.5 0 137.5 +Ang II 140 +Ang II mmol/L 137.5 140 Supplementary Figure 2

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