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Antibody Drug Conjugates Against Tumor Stroma: What Can We Do?

Antibody-drug Conjugates or ADCs are highly targeted biopharmaceutical drugs that combine monoclonal antibodies specific to surface antigens present on particular tumor cells with highly potent anti-cancer agents linked via a chemical linker. The linker plays a key role in determining the pharmacokinetic properties, therapeutic index, selectivity and the overall success of the ADC.

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Antibody Drug Conjugates Against Tumor Stroma: What Can We Do?

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  1. Biochempeg https://www.biochempeg.com Antibody Drug Conjugates Against Tumor Stroma: What Can We Do? Antibody-drug Conjugates or ADCs are highly targeted biopharmaceutical drugs that combine monoclonal antibodies specific to surface antigens present on particular tumor cells with highly potent anti-cancer agents linked via a chemical linker. The linker plays a key role in determining the pharmacokinetic properties, therapeutic index, selectivity and the overall success of the ADC. PEG-linkers are particularly attractive as a linker for conjugation. Water solubility, lack of toxicity; low immunogenicity and well defined chain lengths and molecular weights are specific characteristics of PEG moieties relevant to pharmaceutical applications. Biochempeg develops a broad range of PEG linkers and provides custom linker synthesis for clients worldwide.

  2. Biochempeg https://www.biochempeg.com

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