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Exploring Mobile Elements in Mycobacteriophages: Insights from Bioinformatics

This study delves into the evolution and classification of mobile elements in mycobacteriophages using bioinformatics. We focus on MPEME1 and MPEME2, analyzing sequences from Cluster F phages like Fruit Loop, DotProduct, Bobi, Yoshi, and Taj. By running comparative genomic methods, we examine sequence relationships, repetitive sequences, and the presence of mobile elements, identifying mutations at specific positions. Our findings contribute to understanding the roles of ultra-small mobile genetic elements, with results currently undergoing further comparison.

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Exploring Mobile Elements in Mycobacteriophages: Insights from Bioinformatics

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  1. Mobile elements existence in mycobacteriophages Farah DahmanBioinformatics 301

  2. Background information • Evolution of mycobacteriophage (transposons) (mosaicism) • Mobile Elements MPEME1 & MPME2

  3. Method • Phages studied: Cluster F (average length- 57,422bp)Fruit Loop, DotProduct, Bobi, Yoshi, Taj  

  4. METHOD CONTINUED • Run this method for each phage -compared sequence relations -repetitive sequence within each? -Mobile Element possibility

  5. How to know if mobile element found • Classified their phages to have mobile element in them • 5′-TTATC[a/t]GGGGT-3’MPEME1MPEME2 changes at positon 8 • If find in phages, find match “MycobacteriophagesBPs, Angel and Halo: comparative genomics reveals a novel class of ultra-small mobile genetic elements.”

  6. Conclusion • Results still being compared

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