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4. Endometrial carcinoma

4. Endometrial carcinoma. * Incidence: The commonest malignant tumor in female genital system. * Age: usually post-menopausal 55-65 years. * Predisposing factors: 1. Familial predisposition. 2. Nullipara . 3. Hyperesterism . 4. Endometrial polyp.

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4. Endometrial carcinoma

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  1. 4. Endometrial carcinoma

  2. * Incidence: • The commonest malignant tumor in female genital system. * Age: usually post-menopausal 55-65 years. * Predisposing factors: 1. Familial predisposition. 2. Nullipara. 3. Hyperesterism. 4. Endometrial polyp.

  3. * Grossly: endometrial carcinoma presents either as a localized polypoid tumor or as a diffuse tumor involving the entire endometrial surface. Spread generally occurs by direct myometrial invasion with eventual extension to the periuterine structures by direct spread.

  4. Endometrial carcinoma

  5. * Microscopically; most endometrial carcinomas (about 85%) are adenocarcinomas characterized by more or less well-defined gland patterns closely resembling normal endometrial epithelium.

  6. Endometrial carcinoma

  7. 5. Cancer cervix

  8. * Age: around 40 years. * Risk factors: a. Sexual activity: • Early marriage. • multiple sexual partners. b. Multiparity. c. Oncogenic virus: HPV. d. Precancerous epithelial lesions: • Squamous cell papilloma. • Squamous metaplasia.

  9. *Grossly: • Common at the squamo-columnar junction. • May be fungating, ulcerative or infiltrative.

  10. Cancer cervix

  11. * Microscopically: 1. Squamous cell carcinoma (95%) from ectocervix or endocervix had undergone squamous Metaplasia. 2. Adenocarcinoma (5%) from endocervix.

  12. Squamous cell carcinoma of the cervix

  13. Adenocarcinoma of the cervix

  14. Thanks

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