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Designing Against Endocrine Disruption: Why and How

Designing Against Endocrine Disruption: Why and How. P. L. deFur Environmental Stewardship Concepts, LLC & Virginia Commonwealth U. Biologists- toxicologists and chemists- green chemists started this conversation. Growing recognition of links to many of today’s epidemics.

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Designing Against Endocrine Disruption: Why and How

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  1. Designing Against Endocrine Disruption: Why andHow P. L. deFur Environmental Stewardship Concepts, LLC & Virginia Commonwealth U

  2. Biologists- toxicologists and chemists- green chemists started this conversation

  3. Growing recognition of links to many of today’s epidemics Hormone- related Cancers, Endometriosis, Auto-immunity, Learning disabilities, ADHA, Fibroids, Policycystic ovary Syndrome, Degenerative diseases, Pre-term births, obesity, Diabetes, Heart disease, Asthma, Infertility, Autism Slide Courtesy of Environmental Health Sciences

  4. Common mechanisms Conserved processes Over 100 years of mammalian endocrinology Hormones in all animals A common realization of underlying biology of hormones and health Figure 1

  5. Figure 2 Common interests met at the molecular level

  6. Given what we know of endocrine action, and cell, tissue, animal levels of response, how to plan ahead? Figure 3

  7. Table 1 Overarching principles guiding design of TiPED

  8. Use all tools and approaches: in silico, in vitro, in vivo Figure 4- the TiPED strategy

  9. QSAR Figure 5 The estrogen receptor with BPA in the ligand binding domain- example for a molecular docking model

  10. Table 2 General principles for selection and evaluation of EDC assays for Green Chemists

  11. Table 3 Criteria to guide evaluation of laboratories

  12. The paper • Tiered Protocol for Endocrine Disruption (TiPED) • Green Chemistry 2013,15, 181-198Cite this: DOI: 10.1039/c2gc35055f • www.rsc.org/greenchem

  13. ? http://tiped.org/ 42

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