1. Enzymes 2nd Year Dentistry By Eman Mokbel Alissa, Ph.D.

2. Lecture (1): Lecture Content • Enzyme Definition • Enzymes vs. biological catalysts • Enzyme Nomenclature • Recommended name and IUBMB system • Enzyme Classification • Simple and complex enzymes

3. Lecture (2): Lecture Content • Coenzymes • Properties of enzymes: • Catalytic efficiency • Location within cell • Enzyme active site • Specificity • 2 hypothesis of enzyme specificity

4. Lecture (3): Lecture Content • Mechanism of enzyme action • Mechanism of enzyme catalysis • The Enzyme Substrate Complex • Factors Affecting Reaction Velocity

5. Lecture (4): Lecture Content • Enzymes Kinetics • Michaelis-Menten equation • Linweaver-plot • Types of Enzyme Specificity • Mechanisms of enzyme catalysis

6. Lecture (5): Lecture Content • Enzymes Inhibitors: • Reversible and irreversible • Competitive and uncompetitive • Medical relevance of enzyme Inhibitors • Antibiotics • Enzymes Clinical Application

7. Lecture (6): Lecture Content • Common Terminology • Allosteric enzymes • Allosterism vs. cooperativity • Allosteric Enzymes Kinetics • Feed back inhibition • Homotropic and Heterotropic effectors • Enzyme Activity Regulation • Induction and repression • Covalent modification • Compartmentalization

8. Lecture (7): Lecture Content • Enzyme measurements • Plasma Enzymes • Serum enzymes in Diagnosis • Isoenzymes