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Narcan Overview

Narcan Overview. Narcan. Classification —Synthetic opioid antagonist Mechanism —Competes for opioid receptor sites. Displaces previously administered opioids from their receptors. Indications —Opioid induced collapse; hemodynamic instability and respiratory depression

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Narcan Overview

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  1. Narcan Overview

  2. Narcan Classification—Synthetic opioid antagonist Mechanism—Competes for opioid receptor sites. Displaces previously administered opioids from their receptors. Indications—Opioid induced collapse; hemodynamic instability and respiratory depression -Cardiovascular collapse with airway compromise and a differential diagnosis of drug abuse

  3. Narcan Contraindications—Hypersensitivity to Naloxone (Morphine-like opioids) Dose--Unconscious/overdose: 0.4 mg IV or 0.8 mg SC Route and Methods of Administration—IV push; repeat as indicated (per protocol) SC; repeat as indicated (per protocol)

  4. Narcan Onset, Duration—Less than 2 minutes 30 to 60 minutes (IV) Elimination—Liver; half-life of 60 to 90 minutes (IV)

  5. Narcan Side Effects: CNS--Excitation due to abrupt reversal of analgesia -Tremulousness CVS—Tachycardia -Hypertension -Arrhythmias Skin--Sweating

  6. Narcan Special Considerations • Can cause abrupt state of narcotic withdrawal in the physically dependent patient. • Side effects such as agitation and aggressiveness can be symptoms of narcotic withdrawal. • Naloxone's half-life (60 to 90 minutes) is shorter than that of all opioids; therefore, a patient must be observed until the narcotic effect has worn off. • All patients treated with Naloxone must be transported to hospital

  7. Commonly Abused Opiates • Codeine • Heroin • Morphine • Demerol • Amileridine (Leritine) • Methadone • Hydromorphone (Dilaudid) • Fentanyl • Opium • Pentayocine (Talwin) • Percocet (Percodan)

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