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MCB 135K Discussion

MCB 135K Discussion. April 27, 2005. Topics. Urinary System Male Reproductive System Female Reproductive System. Table 19-1 Major Functions of the Kidney Water and electrolyte regulation Metabolic products excretion Hydrogen ion excretion and maintenance of blood pH

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MCB 135K Discussion

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  1. MCB 135K Discussion April 27, 2005

  2. Topics • Urinary System • Male Reproductive System • Female Reproductive System

  3. Table 19-1 • Major Functions of the Kidney • Water and electrolyte regulation • Metabolic products excretion • Hydrogen ion excretion and maintenance of blood pH • Endocrine functions: • Renin-angiotensin secretion (blood pressure) • Vitamin D activation (Ca++metabolism) • Erythropoietin secretion (hematopoiesis)

  4. Table 19-2 Common Renal Problems in the Elderly Renal Failure Impaired drug excretion Urinary tract infections Hypertension Miscellaneous disorders: Tuberculosis Nephritis Diabetes, etc.

  5. Table 19-3 Some Signs of Renal Failure Generalized edema Acidosis Increased circulating non-protein nitrogen (urea) Increased circulating urinary retention products

  6. Table 19-4 • Selected Causes of Acute Renal Failure • PRE-RENAL: • Loss of body fluids • Inadequate fluid intake • Surgical shock or myocardial infarction • RENAL: • Drug toxicity • Immune reactions • Infectious diseases • Thrombosis • POST-RENAL: • Urinary tract obstruction

  7. Table 19-6 Drugs and the Aging Kidneys Questions: Is the drug excreted primarily by the kidney? How competent are the kidneys? What are the side-effects? What are the consequences of drug toxicity when the kidney is impaired? Etiopathology of Renal Drug Toxicity: High renal blood flow Increased drug concentration and accumulation in kidney Increased hepatic enzyme inhibition in the elderly Increased autoimmune disorders in the elderly

  8. Table 19-8 Age-Related Changes Contributing to Incontinence In Females Estrogen deficiency Weak pelvic floor and bladder outlet Decreased urethral muscle tone Atrophic vaginitis In Males Increased prostatic size Impaired urinary flow Urinary retention Detrusor muscle instability

  9. Anatomy of the Male Reproductive Tract • In humans the principal reproductive organ is the brain • In addition to the brain, the male reproductive system consists of the: TESTIS Primary sex organ suspended outside of the body in the scrotum Secondary male sex organs include: EPIDIDYMIS, VAS DEFERENS, EJACULATORY DUCTS which carry sperm to the urethra SEMINAL VESISCLES, PROSTATE, & BULBOURETHRAL GLANDS which secrete seminal fluid PENIS with URETHRA through which flow both urine and semen

  10. A simplified version of the male reproductive endocrinology: The hypothalamus releases GnRH into the circulatory system and, through blood, directly into the pituitary. GnRH triggers the release of the pituitary LH and FSH that stimulate the testes to testosterone secretion and sperm production.

  11. The testis, the male primary reproductive organ, contains three types of cells, all necessary for reproduction: the GERM CELLS or GAMETES, involved in fertilization. the INTERSTITIAL CELLS of LEYDIG that secrete testosterone, the major androgen the SERTOLI CELLSwith secretory and reproductive functions

  12. With Age: • On the average, the male reproductive function remains normal (or only slightly diminished in some individuals) until advanced old age (80+ years) when itdecreases • Subtle changes include: GnRH Sensitivity of androgen secretion to LH Sensitivity of negative feedback between GnRH and LH

  13. Table 19-13 • Normal Aging of the Prostate • After age 40: • Outer regions: • Atrophy of smooth muscle and proliferation of connective tissue • Flattening of secretory epithelium • Inner region: • Increase in the number of cells present (hyperplasia) • After age 60: • Slower, but more uniform atrophy of the prostate • Accumulation of prostate concretions

  14. Table 19-12 • The Prostate and Testosterone • The healthy prostate is dependent on androgens for growth • In the prostate: testosterone  dihydrotestosterone (DHT) • The enzyme catalyzing this reaction is 5--reductase • DHT stimulates growth of the prostate

  15. Treatment of Prostate Cancer Depends on Life expectancy Overall health status Personal preferences Size of the prostate State of disease Treatments include: Watchful waiting Surgery Radiation Therapy Hormonal Therapy Cryotherapy **PSA controversary pp. 353, 354**

  16. Ovary Characteristics • Ovaries • Contain germinal cells • Contain endocrine producing cells • Thecal • Granulosa • Determine secondary structures and sexual characteristics

  17. Hypothalamus GnRH Pituitary FSH, LH Ovaries E2, P

  18. Normal Female Hormone Patterns

  19. Gonadotropins: LH Change to pulsatile pattern: hDuration, iFrequency FSH “Monotropic FSH h 1st Noticed prior to any change in cycle length Ovarian Steroidal Hormones Estrone levels h early in the cycle in older ovulatory women Possible due to LH/FSH alterations Eventually, H-P-G axis is unable to generate LH surge needed for ovulation Hormonal Changes From Aging

  20. Abnormalities in Older Oocyte Change in microtubule and chromosome placement at the second metaphase of meiosis May be linked to increased aneuploidy seen in offspring of older women Declining Follicular Reserve 2 Million Primordial Follicles during fetal development Declines to 1 million at birth and 250,000 by puberty Primordial Follicles develop to primary and secondary follicles independent of hormone status In the absence of LH/FSH, follicles undergo atresia Once follicles are depleted, ovarian hormone production declines Ovarian Structural Changes

  21. Menopause Symptoms • Hot Flashes • Most common reported symptom • 70-80 % of women report signs of hot flashes • This rate increases in women with oopherectomy and thin women that smoke • Asian women have much lower rate • 10-25 % Reported • Possibly due to genetics, diet, lack of reporting

  22. Physiological Characteristics of Hot Flashes • Sweating • Increased Skin Conductance • Increased Core Body Temperature • Increased Metabolic Rate • Increased Skin Temperature • Hot flashes appear to be the result of noradrenergic control independent of estrogen regulation • ERT alleviates the symptoms of hot flashes • Adrenergic receptor agonists also show promise for treatment

  23. Effects on Non-Reproductive Steroidal Targets • Skin • Thinning of epidermis • Atrophy of sebaceous glands • Increased sensitivity to temperature, humidity, and trauma • Bladder • General Atrophy • Results in urinary incontinence • Hair • Body hair undergoes redistribution

  24. Menopause and Non-reproductive Targets • Skeletal System • Osteoporosis • Decreased bone mass following menopause that appears to be the result of declining estrogen level • Central Nervous System • Psychological • Anxiety/Depression • Cognition/Memory • Cardiovascular System • Possibly due to role of estrogen in lipid metabolism

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