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EFFECTS WORKING GROUP

The IRSN Effects Working Group, led by Tom Hinton, focuses on enhancing dose-effect modeling to support risk assessments and establish consensus on methodologies for deriving screening level values and protection thresholds. Key initiatives include updating the dose-effect database, analyzing dose-response relationships, incorporating population models, and reviewing alternatives for screening levels. The group aims to develop comprehensive guidance documents by examining multiple stressors and Canadian benthic data, facilitating collaboration among participating countries and organizations.

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EFFECTS WORKING GROUP

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  1. EFFECTS WORKING GROUP Tom Hinton; IRSN; France BROAD OBJECTIVES • Dose – Effect Modelling to assist Risk Assessments • Mathematical Derivation of Screening Level Values / Protection Thresholds • Reach Consensus; Document Methods; Publish Guidance

  2. EFFECTS GROUP Active Participants

  3. EFFECTS GROUP Outline of Working Plan • UPDATE Dose-Effect DATABASE (11; A. Real; Spain; July ‘09) • ( UNSCEAR; post 2006; Russian/Ukrainian) • DOSE – RESPONSE Relationships (13; J. G-L; IRSN; July ’11; PROTECT) • Species Sensitivity Distributions (acute vs chronic; field- vs lab-derived; • at various taxonomic levels) • 3) Incorporate POPULATION MODELS (9; T. Sazykina; Russia; Jan. ‘11) • (Review existing models; life history data; data analyses) • 4) Alternative Approaches (9; T. Sazykina; Russia; Jan. ’11; ICRP comm. 5) • (will non-parametric and Bayesian methods produce screening levels similar to SSD?)

  4. EFFECTS GROUP Outline of Working Plan • 5) Multiples Stressors (13; H. Vandenhove; Belgium; Dec. ’10; IUR) • (Review literature; chemical industry; report on applicability to IAEA; collaborative exp.) 6) Canadian Benthic Data (4; S. Mihok; Canada; July ‘09) (Uranium mining; derive dose to benthos; multivariate stats) • 7) Develop and Publish Guidance Documents (21; T. Hinton; France; July. ‘11) • (Documentation of methods to derive screening levels; guidance on use of screening levels; guidance in conducting effects type research) 8) Final Reports to IAEA (21; T. Hinton; France; Jan. ‘12)

  5. EFFECTS GROUP Next Meeting June or July of 2009; Monaco or Vienna; with BIOTA Working Group

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