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Immunohistochemical Analysis of 15-PGDH in Primary CRCs and Matched CRCLMs

This study investigates 15-PGDH immunoreactivity in tissue microarrays from primary colorectal cancers (CRCs) and corresponding colorectal cancer liver metastases (CRCLMs). Representative immunohistochemical (IHC) images are provided, illustrating scores from 1-4. Comparative analyses reveal that 15-PGDH scores were higher in the central tissue regions of CRCLMs compared to peripheral regions, with synchronous CRCLMs highlighted in red and metachronous in blue. Notably, 15-PGDH levels did not significantly differ in primary CRCs between these regions (p=0.75; Wilcoxon Rank Test).

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Immunohistochemical Analysis of 15-PGDH in Primary CRCs and Matched CRCLMs

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  1. A B P C P C 4 4 3 3 Primary CRC CRCLM 2 2 1 1 1 3 0 0 2 Supplementary Figure 2. 15-PGDH IHC on tissue microarrays of primary CRCs and matched CRCLM. A) Representative 15-PGDH IHC for scores 1-4. Size bars = 100 mm. B) 15-PGDH scores of peripheral (P) and central (C) tissue from primary CRCs and matched CRCLM. Synchronous CRCLMs are shown in red and metachronous CRCLMs in blue. Values are shown only for complete data pairs for both primary tumours and CRCLM. 15-PGDH immunoreactivity was higher in central tissue than the peripheral region of CRCLM, but not in the primary CRCs from the same patients (p<0.01 and p=0.75 respectively; Wilcoxon Rank Test) 2 4

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