1 / 52

Steam Sterilisation - Liquid Filters

Steam Sterilisation - Liquid Filters. Intermediate Level Module 21A. Objectives. Represent a typical LIQUID filter Steam In Place (SIP) procedure Highlight potential problems and offer solutions. Some Questions. Why Steam? To STERILISE the filter and probably downstream pipework

tanner
Télécharger la présentation

Steam Sterilisation - Liquid Filters

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Steam Sterilisation - Liquid Filters Intermediate Level Module 21A

  2. Objectives • Represent a typical LIQUID filter Steam In Place (SIP) procedure • Highlight potential problems and offer solutions

  3. Some Questions • Why Steam?To STERILISE the filter and probably downstream pipework • Minimum Requirements?Time = 20 mins Temperature = 1210CPressure = 1.0 bar g

  4. CAUTION !! • All cartridge filters will have a finite steam life under optimum steaming conditions. Poor steaming conditions WILL reduce the steam life of a cartridge filter • Filter cartridges with a polypropylene core are more susceptible to damage at high temperature • To prevent cartridge filter damage during steaming avoid excess differential pressure at high temperature

  5. “How To” Guide • These guides give step by step instructions for the SIP of a typical LIQUID filter system • They can be used to check actual SIP methods • They should be used as the basis for writing customer-specific SIP procedures

  6. LIQUID FILTER SIP THE PROBLEM ! PHOTO OF BLOCKED/DAMAGED PALL

  7. Liquid filters - The Ideal Set-up STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  8. Remember • It is very unlikely the existing system will exactly match the “ideal” layout • Use the principles and procedures from this training to evaluate or constructively evaluate an existing system • Practically adapt the typical system to meet the system requirements

  9. Note • Liquid filters should be steamed in the FORWARD direction only • Details of maximum steam temperatures and steam life for specific filters are given in the relevant data sheets

  10. Valve Sequence for Product Liquid Flow STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  11. Drain the Product - This is best achieved using a compressed air chase STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  12. Drain the Product. This is best achieved using a compressed air chase Isolate the filter system for Steam In Place (SIP) STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  13. Valve positions Pre SIP STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  14. Open valves V 4, V 6 and V7 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  15. Open valves V 4, V 6 and V7 = Pipework HOT STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  16. When the steam trap (ST 2) below V 5 closes, slowly open V 5 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  17. When the steam trap below V 5 closes, slowly open V 5 Note the steam flow across the filter STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  18. When the steam trap below V 5 closes, slowly open V 5 Note the steam flow across the filter When LIVE steam flows from valve V 4, slowly close V 4 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  19. When LIVE steam flows from valve V 4, slowly close V 4 This will direct the steam flow through the filter STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  20. When LIVE steam flows from valve V 4, slowly close V 4 This will direct the steam flow through the filter The differential pressure (dp) must not exceed 0.2-0.34 bar g (3-5psi) dp = P1- P2 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  21. The differential pressure (dp) must not exceed 0.2-0.34 bar g (3-5psi) When the Steam Trap (ST 3) below valve V7 closes the system pressure will begin to rise STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  22. When the Steam Trap (ST 3) below valve V7 closes the system pressure will begin to rise. Sterilisation = 1210C for 20mins -Reduced time and or temperature would NOT guarantee sterility STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  23. Sterilisation = 1210C for 20mins.Reduced time and or temperature would NOT guarantee sterility Sensor T 1 must maintain 1210C for the 20 mins STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  24. Sensor T 1 must maintain 1210C for the 20 mins The differential pressure (dp) must not exceed 0.2-0.34 bar g (3-5psi) STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  25. On completion of the steam sterilisation cycle, close valves V 2, V 5 and V 7 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  26. On completion of the steam sterilisation cycle, close valves V 2, V 5 and V 7 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  27. On completion of the steam sterilisation cycle, close valves V 2, V 5 and V 7 Slowly open valve V 4 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  28. On completion of the steam sterilisation cycle, close valves V 2, V 5 and V 7. Slowly open valve V 4 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  29. Slowly open valve V 4 Allow the steam to exit the system until pressure gauges P1 and P2 display 0 bar g STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  30. Allow the steam to exit the system until pressure gauges P1 and P2 display 0 bar g During this process the differential pressure (dp) must not exceed 0.2-0.34 bar g (3-5psi) STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  31. Close valve V 4 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  32. Close valve V 4 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  33. Close valve V 4 Allow the filter temperature to fall to the normal operating temperature STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  34. Close valve V 4 Allow the filter temperature to drop to the normal operating temperature STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  35. Allow the filter temperature to drop to the normal operating temperature During the cooling period ensure a vacuum in excess of 0.34 bar g (5psi) is not produced STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  36. During the cooling period ensure a vacuum in excess of 0.34 bar g (5psi) is not produced Close valve V 6 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  37. During the cooling period ensure a vacuum in excess of 0.34 bar g (5psi) is not produced . Close valve V 6 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  38. During the cooling period ensure a vacuum in excess of 0.34 bar g (5psi) is not produced Close valve V 6 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  39. For PROCESS sterilisation Ensure valve V 2 is closed and V 3 and V 7 are open STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  40. For PROCESS sterilisation Ensure valve V 2 is closed and V 3 and V 7 are open. This PREVENTS the filter and the process being steam sterilised at the same time STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  41. Open valve V 8 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  42. Open valve V 8 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  43. Open valve V 8 Allow the temperature to increase to the sterilisation minimum STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  44. Allow the temperature to increase to the sterilisation minimum. Hold the minimum temperature for the minimum time STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  45. Hold the minimum temperature for the minimum time Close valves V 3, V 7 and V 8 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  46. Hold the minimum temperature for the minimum time Close valves V 3, V 7 and V 8 STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  47. Close valves V 3, V 7 and V 8 Allow the process to cool STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  48. Close valves V 3, V 7 and V 8 Allow the process to cool STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  49. Valve Sequence for Product Liquid Flow STEAM P1 V 4 V 8 T1 P2 V 1 V 2 V 3 PRODUCT LIQUID V 5 V 7 V 6 STEAM ST 2 ST 1 ST 3 PROCESS

  50. Liquid Filter SIP - Check List • Ensure the system is fully drained prior to starting the SIP • Flow steam across the filter to an open vent or drain before attempting to flow steam through the filter • Monitor the differential pressure during SIP • Do not generate high steam flow through the filter by steaming to an ‘open end’

More Related