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Immunomodulation in Homotoxicology

Immunomodulation in Homotoxicology. Juan Carlos Herrera Correa, MD. Immunological tolerance. Hyporeactivity or non-reactivity of the immune system to an antigen, induced by previous contact with this antigen. IL 10. -TGF. Tolerogenic. Reparative. MALT. MALT. NALT LALT BALT GALT

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Immunomodulation in Homotoxicology

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  1. Immunomodulation in Homotoxicology Juan Carlos Herrera Correa, MD

  2. Immunological tolerance Hyporeactivity or non-reactivity of the immune system to an antigen, induced by previous contact with this antigen Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  3. IL 10 • -TGF Tolerogenic Reparative

  4. MALT

  5. MALT NALT LALT BALT GALT SALT

  6. Czerkinsky, Cecil; Anjuere, Fabienne; McGhee, Jerry R.; George-Chandy, Annie; Holmgren, Jan; Kieny, Marie-Paule; Fujiyashi, Kohtaro; Mestecky, Jiri F.; Pierrefite-Carle, Valérie; Rask, Carola; Sun, Jia-Bin. Mucosal immunity and tolerance: relevance to vaccine development. Immunological Reviews. Volume 170 August 1999 pp 197-222.

  7. Mucosa-Associated Lymphoid Tissues Brandtzaeg, P. Homing of mucosal immune cells-a possible connection between intestinal and articular inflammation. Alimentary pharmacology & Therapeutics, Supplement. Volume 11 Supplement 3  December 1997 pp 24-39. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  8. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  9. Patients who are allergic to cow’s milk show increased intestinal permeability. • Van Elburg RM, Heymans HS, De Monchy JG. Effect of disodium cromoglycate on intestinal permeability changes and clinical response during cow’s milk challenge. Pediatr Allergy Immunol 1993; 4:79–85. • Schrander JJ, Unsalan-Hooyen RW, Forget PP, et al. [51Cr] EDTA intestinal permeability in children with cow’s milk intolerance. J Pediatr Gastroenterol Nutr 1990; 10:189–92. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  10. Immunological tolerance and intestinal mucosa • Barrier mechanism: secretion of mucus • Intestinal flora • Mucosal integrity • IgA • MALT regulation mechanisms Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  11. Antigen presentation Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  12. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  13. Antigen presentation Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  14. Antigen APC Macrophage CD8 M. Rosales Sdme de Inflamación de las Mucosas. 2nd edition MHC PROCESSEDANTIGEN TCR Th0 IL-10 Th3 Th1 Th2 TGF-B IL-10 IL2, IFN-G, TNF-A IL4, IL5, IL6 IL9, IL10, IL13 Th1 B B Cell-mediated immunity Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006 IGM, IgE, IgG IGA

  15. How does the body react to the entry of an antigen? • Production of antibodies • Anergy or apoptosis • Immunological tolerance Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  16. Normal response in CD 4 + T lymphocytes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  17. Types of response Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  18. Immunological tolerance Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  19. Schmidt-Weber, C. B.; Blaser, K. T-cell tolerance in allergic response. Allergy: European Journal of Allergy and Clinical Immunology. Volume 57(9)  September 2002 pp 762–768 Swiss Institute for Allergy and Asthma Research, Switzerland

  20. Tolerance mechanisms1. Insufficient co-stimulation Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  21. Without co-adjuvants Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  22. Tolerance mechanisms1. Insufficient co-stimulation2. Abundant soluble antigen without adjuvants Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  23. Tolerance mechanisms1. Insufficient co-stimulation2. Abundant soluble antigen without adjuvants3. CTLA4 receptors Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  24. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  25. “Cytolytic T lymphocytes” Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  26. Tolerance mechanisms1. Insufficient co-stimulation2. Abundant soluble antigen without adjuvants3. CTLA4 receptors 4. Slight mutation of antigen structure Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  27. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  28. Tolerance mechanisms1. Insufficient co-stimulation2. Abundant soluble antigen without adjuvants3. CTLA4 receptors 4. Slight mutation of antigen structure5. APC-mediated suppression Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  29. IL 10 Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  30. Tolerance mechanisms1. Insufficient co-stimulation2. Abundant soluble antigen without adjuvants3. CTLA4 receptors 4. Slight mutation of antigen structure5. APC-mediated suppression6. Bystander suppression Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  31. Bystandersuppression Immunological bystander reaction Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  32. Immunological bystander reaction Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  33. Immunological bystander reaction (IBR) Special kind of “low dose antigen reaction” Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  34. Entry Oral Mucosa-associated lymphoid tissue MALT Other routes Immunological cells of the matrix Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  35. The potentized proteins of the medicines are immunologically challenged by antigen presenting cells Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  36. IBR Antigen presenting cells APC Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  37. IBR Phagocytosis Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  38. IBR D1-D14 Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  39. IBR Processing in proteasomes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  40. IBR Digestion by lysosomes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  41. IBR Short sequences of amino acids (9-15) Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  42. IBR Coupling to MHC class II Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  43. IBR Transport via vacuoles Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  44. IBR To the cell membrane Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  45. IBR Anchorage in glycocalyx Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  46. IBR Expression of epitopes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  47. IBR Patrolling lymphocytes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  48. IBR CD4 T lymphocytes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  49. IBR APC-lymphocyte complex Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

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