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In-home Coal Use and Lung Cancer Risk

This study investigates the association between in-home coal use and the risk of developing lung cancer. The researchers conducted a case-control study and analyzed data from various databases. The results suggest a significant increase in lung cancer risk associated with coal use in the home.

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In-home Coal Use and Lung Cancer Risk

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  1. In-home Coal Use and Lung Cancer Risk H. Dean Hosgood, III, PhD, MPH Qing Lan, PhD, MDOccupational & Environmental Epidemiology BranchDivision of Cancer Epidemiology and Genetics National Cancer Institute

  2. Search Strategy – Keywords • Air pollution keywords and • ("IAP" OR "Indoor air" OR "pollution" OR "pollutant" OR "fuel" OR "fuels" OR "coal" OR “coals” OR "charcoal" OR “charcoals” OR “cake” OR “cakes” OR “briquette” OR “briquettes” OR “solid fuel” OR “solid fuels” OR “biomass” OR “anthracite” OR “bituminous” OR “fossil fuel” OR “fossil fuels” OR “lignite” OR “subbituminous” OR "stove" OR "stoves" OR "chula" OR "chulla" OR "oven" OR "ovens" OR "smoke" OR "smoky" OR heat* OR cook* OR light* OR burn*) AND • Lung cancer keywords • ("lung" OR "bronchus" OR "bronchial" OR "bronchogenic" OR "pulmonary" OR "lower respiratory tract" OR "trachea") AND • ("cancer" OR "cancers" OR "carcinoma" OR "carcinomata" OR "neoplasm" OR "neoplasms" OR "tumor" OR "tumors" OR "tumours" OR "tumour" OR "adenocarcinoma" OR "adenocarcinomata" OR "*small-cell") Hosgood et al.

  3. Search Strategy – Databases • PubMed and Science Citation Index • Studies in humans published January1966 - June 2009 • China National Knowledge Infrastructure and Science Periodical Database of China • Articles published through June 2009 with in: • (A)Mathematics/ Physics/ Mechanics/ Astronomy • (B) Chemistry/ Metallurgy/ Environment/ Mine Industry • (C) Architecture/ Energy/ Traffic/ Electromechanics • (D) Agriculture • (E) Medicine & Public Health • (F) Literature/ History/ Philosophy • (G) Politics/ Military Affairs/ Law • (H) Education & Social Sciences • (I) Electronic Technology & Information Science • (J) Economics & Managementusing models Hosgood et al.

  4. Search Strategy – Additional Searches • Reviewed bibliography of all published articles reviewed in full • Reviewed bibliography of the two previously published meta-analyses in Chinese • Reviewed bibliography of previous IARC monograph Hosgood et al.

  5. Inclusion Criteria • Case-control study • Provide OR and 95%CI or enough information to calculate OR and 95%CI • In-home exposure only, not occupational or urban exposures • Differentiate coal association from other biomass fuels • Population not part of previously published study Hosgood et al.

  6. Studies Identified

  7. Statistical Methods • Used unadjusted OR and 95%CI from each study • Results were similar when using adjusted ORs and 95%Cs from studies that reported them • Random-effects model • Heterogeneity among studies determined by a χ2-based Q-statistic • Funnel plots • Begg’s test Hosgood et al.

  8. 2.18 (1.76-2.70)

  9. 2.18 (1.76-2.70) Hosgood et al.

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